The features of late local recurrences following curative surgery for rectal cancer

Mamoru Uemura, Masataka Ikeda, Mitsugu Sekimoto, Shingo Noura, Masayuki Ohue, Tsunekazu Mizushima, Hirofumi Yamamoto, Ichiro Takemasa, Masahiko Yano, Osamu Ishikawa, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Rectal cancers are characterized by high incidence of local recurrence after curative surgery, in some cases it occurs after 5 years. To determine the features of late locally recurrent rectal cancer (LRRC) is important for its management. Methodology: The medical records of 110 patients with LRRC after curative surgery were reviewed. We examined the relationship between the interval between surgery and appearance of LRRC and various clinicopathological factors by dividing patients into the early (recurrence before 5 years after surgery) and late (recurrence after more than 5 years) recurrence groups. Results: In the late-recurrence group (n=7), well-differentiated adenocarcinoma was significantly higher (p=0.0031) and venous invasion was significantly lower (p=0.0105) than the early-recurrence group (n=113). Multivariate Cox regression analysis identified histological grade and venous invasion of primary lesion as independent predictors for early-onset LRRC (p=0.0396 and p=0.0009, respectively). The presence of symptoms at the time of diagnosis was the only factor that significantly related to resectability of LRRC (p=0.015). Conclusions: For detection of asymptomatic LRRC, which can lead to curative resection, follow-up program after curative resection of rectal cancer should be designed based on the histological grade and venous invasion of primary tumor.

Original languageEnglish
Pages (from-to)1800-1803
Number of pages4
JournalHepato-Gastroenterology
Volume59
Issue number118
DOIs
Publication statusPublished - Sep 1 2012
Externally publishedYes

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Rectal Neoplasms
Recurrence
Medical Records
Adenocarcinoma
Regression Analysis
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Uemura, M., Ikeda, M., Sekimoto, M., Noura, S., Ohue, M., Mizushima, T., ... Mori, M. (2012). The features of late local recurrences following curative surgery for rectal cancer. Hepato-Gastroenterology, 59(118), 1800-1803. https://doi.org/10.5754/hge10832

The features of late local recurrences following curative surgery for rectal cancer. / Uemura, Mamoru; Ikeda, Masataka; Sekimoto, Mitsugu; Noura, Shingo; Ohue, Masayuki; Mizushima, Tsunekazu; Yamamoto, Hirofumi; Takemasa, Ichiro; Yano, Masahiko; Ishikawa, Osamu; Doki, Yuichiro; Mori, Masaki.

In: Hepato-Gastroenterology, Vol. 59, No. 118, 01.09.2012, p. 1800-1803.

Research output: Contribution to journalArticle

Uemura, M, Ikeda, M, Sekimoto, M, Noura, S, Ohue, M, Mizushima, T, Yamamoto, H, Takemasa, I, Yano, M, Ishikawa, O, Doki, Y & Mori, M 2012, 'The features of late local recurrences following curative surgery for rectal cancer', Hepato-Gastroenterology, vol. 59, no. 118, pp. 1800-1803. https://doi.org/10.5754/hge10832
Uemura M, Ikeda M, Sekimoto M, Noura S, Ohue M, Mizushima T et al. The features of late local recurrences following curative surgery for rectal cancer. Hepato-Gastroenterology. 2012 Sep 1;59(118):1800-1803. https://doi.org/10.5754/hge10832
Uemura, Mamoru ; Ikeda, Masataka ; Sekimoto, Mitsugu ; Noura, Shingo ; Ohue, Masayuki ; Mizushima, Tsunekazu ; Yamamoto, Hirofumi ; Takemasa, Ichiro ; Yano, Masahiko ; Ishikawa, Osamu ; Doki, Yuichiro ; Mori, Masaki. / The features of late local recurrences following curative surgery for rectal cancer. In: Hepato-Gastroenterology. 2012 ; Vol. 59, No. 118. pp. 1800-1803.
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