The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages

Reina E. Mebius, Toshihiro Miyamoto, Julie Christensen, Jos Domen, Tom Cupedo, Irving L. Weissman, Koichi Akashi

Research output: Contribution to journalArticlepeer-review

202 Citations (Scopus)

Abstract

We identified an IL-7Rα+Sca-1lowc-Kitlow population in E14 fetal liver, which is the phenotypical analog of common lymphoid progenitors (CLP) in adult bone marrow. After transfer into newborn mice, the IL-7Rα+Sca-1lowc-Kitlow population rapidly differentiated into CD45+CD4+CD3- cells, which are candidate cells for initiating lymph node and Peyer's patch formation. In addition, this population also gave rise to B, T, NK, and CD8α+ and CD8α- dendritic cells. The fetal liver precursors expressed a significantly lower level of the myeloid-suppressing transcription factor Pax-5, than adult CLP, and retained differentiation activity for macrophages in vitro. We propose that the transition from fetal liver IL-7Rα+Sca-1lowc-Kitlow cells to adult CLP involves a regulated restriction of their developmental potential, controlled, at least in part, by Pax-5 expression.

Original languageEnglish
Pages (from-to)6593-6601
Number of pages9
JournalJournal of Immunology
Volume166
Issue number11
DOIs
Publication statusPublished - May 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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