The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors

Hideshi Ishii, Raffaele Baffa, Shin Ichiro Numata, Yoshiki Murakumo, Shashi Rattan, Hiroshi Inoue, Masaki Mori, Vincenzo Fidanza, Hansjuerg Alder, Carlo M. Croce

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Abstract

Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.

Original languageEnglish
Pages (from-to)3928-3933
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number7
DOIs
Publication statusPublished - Mar 30 1999

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Leucine Zippers
Chromosomes
Genes
Neoplasms
Proteins
Activating Transcription Factors
Loss of Heterozygosity
Human Chromosomes
Gene Silencing
Esophageal Neoplasms
Prostatic Neoplasms
Complementary DNA
RNA
Gene Expression
Cell Line
Messenger RNA
Mutation
DNA

All Science Journal Classification (ASJC) codes

  • General

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The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. / Ishii, Hideshi; Baffa, Raffaele; Numata, Shin Ichiro; Murakumo, Yoshiki; Rattan, Shashi; Inoue, Hiroshi; Mori, Masaki; Fidanza, Vincenzo; Alder, Hansjuerg; Croce, Carlo M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 7, 30.03.1999, p. 3928-3933.

Research output: Contribution to journalArticle

Ishii, Hideshi ; Baffa, Raffaele ; Numata, Shin Ichiro ; Murakumo, Yoshiki ; Rattan, Shashi ; Inoue, Hiroshi ; Mori, Masaki ; Fidanza, Vincenzo ; Alder, Hansjuerg ; Croce, Carlo M. / The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 7. pp. 3928-3933.
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AU - Rattan, Shashi

AU - Inoue, Hiroshi

AU - Mori, Masaki

AU - Fidanza, Vincenzo

AU - Alder, Hansjuerg

AU - Croce, Carlo M.

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