Abstract
Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 3928-3933 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 96 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Mar 30 1999 |
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The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. / Ishii, Hideshi; Baffa, Raffaele; Numata, Shin Ichiro; Murakumo, Yoshiki; Rattan, Shashi; Inoue, Hiroshi; Mori, Masaki; Fidanza, Vincenzo; Alder, Hansjuerg; Croce, Carlo M.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 7, 30.03.1999, p. 3928-3933.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
AU - Ishii, Hideshi
AU - Baffa, Raffaele
AU - Numata, Shin Ichiro
AU - Murakumo, Yoshiki
AU - Rattan, Shashi
AU - Inoue, Hiroshi
AU - Mori, Masaki
AU - Fidanza, Vincenzo
AU - Alder, Hansjuerg
AU - Croce, Carlo M.
PY - 1999/3/30
Y1 - 1999/3/30
N2 - Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
AB - Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis, cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.
UR - http://www.scopus.com/inward/record.url?scp=13044313477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13044313477&partnerID=8YFLogxK
U2 - 10.1073/pnas.96.7.3928
DO - 10.1073/pnas.96.7.3928
M3 - Article
C2 - 10097140
AN - SCOPUS:13044313477
VL - 96
SP - 3928
EP - 3933
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 7
ER -