The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan

Shinichi Watanabe, Takamitsu Ohnishi, Akira Yuasa, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Junko Sato, Hideaki Hanaki, Motomu Manabe, Tamio Suzuki, Fujio Otsuka, Michiko Aihara, Ken Iozumi, Takeshi Tamaki, Yuichi Funada, Mikio Shinozaki, Motoko Kobayashi, Masaru Okuda, Go KikyoKumi Kikuchi, Yoshitane Okada, Masanori Takeshima, Osamu Kaneko, Natsuki Ogawa, Rie Ito, Ryuhei Okuyama, Shinji Shimada, Tadamichi Shimizu, Naohito Hatta, Maeda Manabu, Kiyohiro Tsutsui, Toshihiro Tanaka, Yoshiki Miyachi, Hideo Asada, Fukumi Furukawa, Ichiro Kurokawa, Keiji Iwatsuki, Michihiro Hide, Masahiko Muto, Osamu Yamamoto, Hiroyuki Niihara, Kenji Takagaki, Yasuo Kubota, Koji Sayama, Shigetoshi Sano, Masutaka Furue, Takuro Kanekura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To investigate the trends of antimicrobial resistance in pathogens isolated from skin and soft-tissue infections (SSTI) at dermatology departments in Japan, a Japanese surveillance committee conducted the first nationwide survey in 2013. Three main organisms were collected from SSTI at 30 dermatology departments in medical centers and 10 dermatology clinics. A total of 860 strains – 579 of Staphylococcus aureus, 240 of coagulase-negative Staphylococci, and 41 of Streptococcus pyogenes – were collected and shipped to a central laboratory for antimicrobial susceptibility testing. The patient profiles were also studied. Among all 579 strains of S. aureus, 141 (24.4%) were methicillin-resistant (MRSA). Among 97 Staphylococcus epidermidis strains, 54 (55.7%) were methicillin-resistant (MRSE). MRSA and MRSE were more frequently isolated from inpatients than from outpatients. Furthermore, these methicillin-resistant strains were also isolated more frequently from patients with histories of taking antibiotics within 4 weeks and hospitalization within 1 year compared to those without. However, there were no significant differences in MIC values and susceptibility patterns of the MRSA strains between patients with a history of hospitalization within 1 year and those without. Therefore, most of the isolated MRSA cases at dermatology departments are not healthcare-acquired, but community-acquired MRSA. S. pyogenes strains were susceptible to most antibiotics except macrolides. The information in this study is not only important in terms of local public health but will also contribute to an understanding of epidemic clones of pathogens from SSTI.

Original languageEnglish
Pages (from-to)503-511
Number of pages9
JournalJournal of Infection and Chemotherapy
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 2017

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Soft Tissue Infections
Methicillin Resistance
Dermatology
Japan
Skin
Streptococcus pyogenes
Staphylococcus aureus
Hospitalization
Anti-Bacterial Agents
Staphylococcus epidermidis
Coagulase
Macrolides
Staphylococcus
Inpatients
Outpatients
Public Health
Clone Cells
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan. / Watanabe, Shinichi; Ohnishi, Takamitsu; Yuasa, Akira; Kiyota, Hiroshi; Iwata, Satoshi; Kaku, Mitsuo; Watanabe, Akira; Sato, Junko; Hanaki, Hideaki; Manabe, Motomu; Suzuki, Tamio; Otsuka, Fujio; Aihara, Michiko; Iozumi, Ken; Tamaki, Takeshi; Funada, Yuichi; Shinozaki, Mikio; Kobayashi, Motoko; Okuda, Masaru; Kikyo, Go; Kikuchi, Kumi; Okada, Yoshitane; Takeshima, Masanori; Kaneko, Osamu; Ogawa, Natsuki; Ito, Rie; Okuyama, Ryuhei; Shimada, Shinji; Shimizu, Tadamichi; Hatta, Naohito; Manabu, Maeda; Tsutsui, Kiyohiro; Tanaka, Toshihiro; Miyachi, Yoshiki; Asada, Hideo; Furukawa, Fukumi; Kurokawa, Ichiro; Iwatsuki, Keiji; Hide, Michihiro; Muto, Masahiko; Yamamoto, Osamu; Niihara, Hiroyuki; Takagaki, Kenji; Kubota, Yasuo; Sayama, Koji; Sano, Shigetoshi; Furue, Masutaka; Kanekura, Takuro.

In: Journal of Infection and Chemotherapy, Vol. 23, No. 8, 08.2017, p. 503-511.

Research output: Contribution to journalArticle

Watanabe, S, Ohnishi, T, Yuasa, A, Kiyota, H, Iwata, S, Kaku, M, Watanabe, A, Sato, J, Hanaki, H, Manabe, M, Suzuki, T, Otsuka, F, Aihara, M, Iozumi, K, Tamaki, T, Funada, Y, Shinozaki, M, Kobayashi, M, Okuda, M, Kikyo, G, Kikuchi, K, Okada, Y, Takeshima, M, Kaneko, O, Ogawa, N, Ito, R, Okuyama, R, Shimada, S, Shimizu, T, Hatta, N, Manabu, M, Tsutsui, K, Tanaka, T, Miyachi, Y, Asada, H, Furukawa, F, Kurokawa, I, Iwatsuki, K, Hide, M, Muto, M, Yamamoto, O, Niihara, H, Takagaki, K, Kubota, Y, Sayama, K, Sano, S, Furue, M & Kanekura, T 2017, 'The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan', Journal of Infection and Chemotherapy, vol. 23, no. 8, pp. 503-511. https://doi.org/10.1016/j.jiac.2017.05.006
Watanabe, Shinichi ; Ohnishi, Takamitsu ; Yuasa, Akira ; Kiyota, Hiroshi ; Iwata, Satoshi ; Kaku, Mitsuo ; Watanabe, Akira ; Sato, Junko ; Hanaki, Hideaki ; Manabe, Motomu ; Suzuki, Tamio ; Otsuka, Fujio ; Aihara, Michiko ; Iozumi, Ken ; Tamaki, Takeshi ; Funada, Yuichi ; Shinozaki, Mikio ; Kobayashi, Motoko ; Okuda, Masaru ; Kikyo, Go ; Kikuchi, Kumi ; Okada, Yoshitane ; Takeshima, Masanori ; Kaneko, Osamu ; Ogawa, Natsuki ; Ito, Rie ; Okuyama, Ryuhei ; Shimada, Shinji ; Shimizu, Tadamichi ; Hatta, Naohito ; Manabu, Maeda ; Tsutsui, Kiyohiro ; Tanaka, Toshihiro ; Miyachi, Yoshiki ; Asada, Hideo ; Furukawa, Fukumi ; Kurokawa, Ichiro ; Iwatsuki, Keiji ; Hide, Michihiro ; Muto, Masahiko ; Yamamoto, Osamu ; Niihara, Hiroyuki ; Takagaki, Kenji ; Kubota, Yasuo ; Sayama, Koji ; Sano, Shigetoshi ; Furue, Masutaka ; Kanekura, Takuro. / The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan. In: Journal of Infection and Chemotherapy. 2017 ; Vol. 23, No. 8. pp. 503-511.
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abstract = "To investigate the trends of antimicrobial resistance in pathogens isolated from skin and soft-tissue infections (SSTI) at dermatology departments in Japan, a Japanese surveillance committee conducted the first nationwide survey in 2013. Three main organisms were collected from SSTI at 30 dermatology departments in medical centers and 10 dermatology clinics. A total of 860 strains – 579 of Staphylococcus aureus, 240 of coagulase-negative Staphylococci, and 41 of Streptococcus pyogenes – were collected and shipped to a central laboratory for antimicrobial susceptibility testing. The patient profiles were also studied. Among all 579 strains of S. aureus, 141 (24.4{\%}) were methicillin-resistant (MRSA). Among 97 Staphylococcus epidermidis strains, 54 (55.7{\%}) were methicillin-resistant (MRSE). MRSA and MRSE were more frequently isolated from inpatients than from outpatients. Furthermore, these methicillin-resistant strains were also isolated more frequently from patients with histories of taking antibiotics within 4 weeks and hospitalization within 1 year compared to those without. However, there were no significant differences in MIC values and susceptibility patterns of the MRSA strains between patients with a history of hospitalization within 1 year and those without. Therefore, most of the isolated MRSA cases at dermatology departments are not healthcare-acquired, but community-acquired MRSA. S. pyogenes strains were susceptible to most antibiotics except macrolides. The information in this study is not only important in terms of local public health but will also contribute to an understanding of epidemic clones of pathogens from SSTI.",
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AU - Iwatsuki, Keiji

AU - Hide, Michihiro

AU - Muto, Masahiko

AU - Yamamoto, Osamu

AU - Niihara, Hiroyuki

AU - Takagaki, Kenji

AU - Kubota, Yasuo

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