The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility

Y. Niki, H. Hanaki, M. Yagisawa, S. Kohno, N. Aoki, A. Watanabe, J. Sato, R. Hattori, N. Koashi, T. Kozuki, A. Maruo, K. Morita, K. Ogasawara, Y. Takahashi, J. Watanabe, K. Takeuchi, M. Takahashi, H. Takeda, H. Ikeda, H. KanedaK. Niitsuma, M. Saito, S. Koshiba, M. Kaneko, S. Itabashi, M. Miki, S. Nakanowatari, Y. Honda, J. Chiba, H. Takahashi, M. Utagawa, T. Kondo, A. Kawana, H. Konosaki, Y. Aoki, N. Chonabayashi, H. Ueda, H. Sugiura, M. Ichioka, H. Goto, M. Aoshima, M. Okazaki, T. Ozawa, F. Horiuchi, T. Yoshida, H. Tsukada, S. Kobayashi, H. Yoshikawa, Y. Imai, N. Aoki, Y. Honma, K. Yoshida, M. Takaya, Y. Kurokawa, M. Kuwabara, Y. Fujiue, T. Ishimaru, N. Matsubara, Y. Kawasaki, H. Tokuyasu, K. Masui, E. Shimizu, K. Yoneda, K. Negayama, N. Ueda, M. Ishimaru, Y. Nakanishi, M. Fujita, J. Honda, J. Kadota, K. Hiramatsu, Y. Aoki, Z. Nagasawa, M. Suga, H. Muranaka, S. Kohno, K. Yanagihara, J. Fujita, M. Tateyama, K. Totsuka

Research output: Contribution to journalArticle

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Abstract

The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

Original languageEnglish
Pages (from-to)279-290
Number of pages12
JournalJournal of Infection and Chemotherapy
Volume14
Issue number4
DOIs
Publication statusPublished - Aug 2008

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Streptococcus pneumoniae
Haemophilus influenzae
Klebsiella pneumoniae
Anti-Bacterial Agents
Drug Therapy
Respiratory Tract Infections
Penicillins
Pseudomonas aeruginosa
Incidence
Ketolides
Lincosamides
Oxazolidinones
Moraxella (Branhamella) catarrhalis
Lactams
Glycopeptides
Streptococcus pyogenes
Fluoroquinolones
Macrolides
Aminoglycosides
Ampicillin

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1 : A general view of antibacterial susceptibility. / Niki, Y.; Hanaki, H.; Yagisawa, M.; Kohno, S.; Aoki, N.; Watanabe, A.; Sato, J.; Hattori, R.; Koashi, N.; Kozuki, T.; Maruo, A.; Morita, K.; Ogasawara, K.; Takahashi, Y.; Watanabe, J.; Takeuchi, K.; Takahashi, M.; Takeda, H.; Ikeda, H.; Kaneda, H.; Niitsuma, K.; Saito, M.; Koshiba, S.; Kaneko, M.; Itabashi, S.; Miki, M.; Nakanowatari, S.; Honda, Y.; Chiba, J.; Takahashi, H.; Utagawa, M.; Kondo, T.; Kawana, A.; Konosaki, H.; Aoki, Y.; Chonabayashi, N.; Ueda, H.; Sugiura, H.; Ichioka, M.; Goto, H.; Aoshima, M.; Okazaki, M.; Ozawa, T.; Horiuchi, F.; Yoshida, T.; Tsukada, H.; Kobayashi, S.; Yoshikawa, H.; Imai, Y.; Aoki, N.; Honma, Y.; Yoshida, K.; Takaya, M.; Kurokawa, Y.; Kuwabara, M.; Fujiue, Y.; Ishimaru, T.; Matsubara, N.; Kawasaki, Y.; Tokuyasu, H.; Masui, K.; Shimizu, E.; Yoneda, K.; Negayama, K.; Ueda, N.; Ishimaru, M.; Nakanishi, Y.; Fujita, M.; Honda, J.; Kadota, J.; Hiramatsu, K.; Aoki, Y.; Nagasawa, Z.; Suga, M.; Muranaka, H.; Kohno, S.; Yanagihara, K.; Fujita, J.; Tateyama, M.; Totsuka, K.

In: Journal of Infection and Chemotherapy, Vol. 14, No. 4, 08.2008, p. 279-290.

Research output: Contribution to journalArticle

Niki, Y, Hanaki, H, Yagisawa, M, Kohno, S, Aoki, N, Watanabe, A, Sato, J, Hattori, R, Koashi, N, Kozuki, T, Maruo, A, Morita, K, Ogasawara, K, Takahashi, Y, Watanabe, J, Takeuchi, K, Takahashi, M, Takeda, H, Ikeda, H, Kaneda, H, Niitsuma, K, Saito, M, Koshiba, S, Kaneko, M, Itabashi, S, Miki, M, Nakanowatari, S, Honda, Y, Chiba, J, Takahashi, H, Utagawa, M, Kondo, T, Kawana, A, Konosaki, H, Aoki, Y, Chonabayashi, N, Ueda, H, Sugiura, H, Ichioka, M, Goto, H, Aoshima, M, Okazaki, M, Ozawa, T, Horiuchi, F, Yoshida, T, Tsukada, H, Kobayashi, S, Yoshikawa, H, Imai, Y, Aoki, N, Honma, Y, Yoshida, K, Takaya, M, Kurokawa, Y, Kuwabara, M, Fujiue, Y, Ishimaru, T, Matsubara, N, Kawasaki, Y, Tokuyasu, H, Masui, K, Shimizu, E, Yoneda, K, Negayama, K, Ueda, N, Ishimaru, M, Nakanishi, Y, Fujita, M, Honda, J, Kadota, J, Hiramatsu, K, Aoki, Y, Nagasawa, Z, Suga, M, Muranaka, H, Kohno, S, Yanagihara, K, Fujita, J, Tateyama, M & Totsuka, K 2008, 'The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1: A general view of antibacterial susceptibility', Journal of Infection and Chemotherapy, vol. 14, no. 4, pp. 279-290. https://doi.org/10.1007/s10156-008-0623-2
Niki, Y. ; Hanaki, H. ; Yagisawa, M. ; Kohno, S. ; Aoki, N. ; Watanabe, A. ; Sato, J. ; Hattori, R. ; Koashi, N. ; Kozuki, T. ; Maruo, A. ; Morita, K. ; Ogasawara, K. ; Takahashi, Y. ; Watanabe, J. ; Takeuchi, K. ; Takahashi, M. ; Takeda, H. ; Ikeda, H. ; Kaneda, H. ; Niitsuma, K. ; Saito, M. ; Koshiba, S. ; Kaneko, M. ; Itabashi, S. ; Miki, M. ; Nakanowatari, S. ; Honda, Y. ; Chiba, J. ; Takahashi, H. ; Utagawa, M. ; Kondo, T. ; Kawana, A. ; Konosaki, H. ; Aoki, Y. ; Chonabayashi, N. ; Ueda, H. ; Sugiura, H. ; Ichioka, M. ; Goto, H. ; Aoshima, M. ; Okazaki, M. ; Ozawa, T. ; Horiuchi, F. ; Yoshida, T. ; Tsukada, H. ; Kobayashi, S. ; Yoshikawa, H. ; Imai, Y. ; Aoki, N. ; Honma, Y. ; Yoshida, K. ; Takaya, M. ; Kurokawa, Y. ; Kuwabara, M. ; Fujiue, Y. ; Ishimaru, T. ; Matsubara, N. ; Kawasaki, Y. ; Tokuyasu, H. ; Masui, K. ; Shimizu, E. ; Yoneda, K. ; Negayama, K. ; Ueda, N. ; Ishimaru, M. ; Nakanishi, Y. ; Fujita, M. ; Honda, J. ; Kadota, J. ; Hiramatsu, K. ; Aoki, Y. ; Nagasawa, Z. ; Suga, M. ; Muranaka, H. ; Kohno, S. ; Yanagihara, K. ; Fujita, J. ; Tateyama, M. ; Totsuka, K. / The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1 : A general view of antibacterial susceptibility. In: Journal of Infection and Chemotherapy. 2008 ; Vol. 14, No. 4. pp. 279-290.
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abstract = "The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4{\%}, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0{\%} and 4.0{\%}, respectively. Among H. influenzae, 21.2{\%} of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1{\%} to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8{\%} to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7{\%} (2 of 74 strains). Three (2.1{\%}) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7{\%}) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.",
author = "Y. Niki and H. Hanaki and M. Yagisawa and S. Kohno and N. Aoki and A. Watanabe and J. Sato and R. Hattori and N. Koashi and T. Kozuki and A. Maruo and K. Morita and K. Ogasawara and Y. Takahashi and J. Watanabe and K. Takeuchi and M. Takahashi and H. Takeda and H. Ikeda and H. Kaneda and K. Niitsuma and M. Saito and S. Koshiba and M. Kaneko and S. Itabashi and M. Miki and S. Nakanowatari and Y. Honda and J. Chiba and H. Takahashi and M. Utagawa and T. Kondo and A. Kawana and H. Konosaki and Y. Aoki and N. Chonabayashi and H. Ueda and H. Sugiura and M. Ichioka and H. Goto and M. Aoshima and M. Okazaki and T. Ozawa and F. Horiuchi and T. Yoshida and H. Tsukada and S. Kobayashi and H. Yoshikawa and Y. Imai and N. Aoki and Y. Honma and K. Yoshida and M. Takaya and Y. Kurokawa and M. Kuwabara and Y. Fujiue and T. Ishimaru and N. Matsubara and Y. Kawasaki and H. Tokuyasu and K. Masui and E. Shimizu and K. Yoneda and K. Negayama and N. Ueda and M. Ishimaru and Y. Nakanishi and M. Fujita and J. Honda and J. Kadota and K. Hiramatsu and Y. Aoki and Z. Nagasawa and M. Suga and H. Muranaka and S. Kohno and K. Yanagihara and J. Fujita and M. Tateyama and K. Totsuka",
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TY - JOUR

T1 - The first nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy. Part 1

T2 - A general view of antibacterial susceptibility

AU - Niki, Y.

AU - Hanaki, H.

AU - Yagisawa, M.

AU - Kohno, S.

AU - Aoki, N.

AU - Watanabe, A.

AU - Sato, J.

AU - Hattori, R.

AU - Koashi, N.

AU - Kozuki, T.

AU - Maruo, A.

AU - Morita, K.

AU - Ogasawara, K.

AU - Takahashi, Y.

AU - Watanabe, J.

AU - Takeuchi, K.

AU - Takahashi, M.

AU - Takeda, H.

AU - Ikeda, H.

AU - Kaneda, H.

AU - Niitsuma, K.

AU - Saito, M.

AU - Koshiba, S.

AU - Kaneko, M.

AU - Itabashi, S.

AU - Miki, M.

AU - Nakanowatari, S.

AU - Honda, Y.

AU - Chiba, J.

AU - Takahashi, H.

AU - Utagawa, M.

AU - Kondo, T.

AU - Kawana, A.

AU - Konosaki, H.

AU - Aoki, Y.

AU - Chonabayashi, N.

AU - Ueda, H.

AU - Sugiura, H.

AU - Ichioka, M.

AU - Goto, H.

AU - Aoshima, M.

AU - Okazaki, M.

AU - Ozawa, T.

AU - Horiuchi, F.

AU - Yoshida, T.

AU - Tsukada, H.

AU - Kobayashi, S.

AU - Yoshikawa, H.

AU - Imai, Y.

AU - Aoki, N.

AU - Honma, Y.

AU - Yoshida, K.

AU - Takaya, M.

AU - Kurokawa, Y.

AU - Kuwabara, M.

AU - Fujiue, Y.

AU - Ishimaru, T.

AU - Matsubara, N.

AU - Kawasaki, Y.

AU - Tokuyasu, H.

AU - Masui, K.

AU - Shimizu, E.

AU - Yoneda, K.

AU - Negayama, K.

AU - Ueda, N.

AU - Ishimaru, M.

AU - Nakanishi, Y.

AU - Fujita, M.

AU - Honda, J.

AU - Kadota, J.

AU - Hiramatsu, K.

AU - Aoki, Y.

AU - Nagasawa, Z.

AU - Suga, M.

AU - Muranaka, H.

AU - Kohno, S.

AU - Yanagihara, K.

AU - Fujita, J.

AU - Tateyama, M.

AU - Totsuka, K.

PY - 2008/8

Y1 - 2008/8

N2 - The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

AB - The Japanese Society of Chemotherapy (JSC) conducted the first nationwide surveillance of bacterial respiratory pathogens during the period from January to August 2006. With the cooperation of 32 medical institutions throughout Japan, a total of 924 strains belonging to seven clinically relevant bacterial species were collected from adult patients with well-diagnosed respiratory tract infections (RTIs). Antimicrobial susceptibility testing of the 887 evaluable strains (205 Staphylococcus aureus, 200 Streptococcus pneumoniae, 9 Streptococcus pyogenes, 165 Haemophilus influenzae, 91 Moraxella catarrhalis, 74 Klebsiella pneumoniae, and 143 Pseudomonas aeruginosa) to 42 antibacterial agents was conducted at the Central Laboratory of the Research Center for Anti-infective Drugs of the Kitasato Institute, according to recommendations issued by the Clinical and Laboratory Standards Institute (CLSI). The antibacterial agents employed were 25 β-lactams, three aminoglycosides, four macrolides (including one azalide and one ketolide), one lincosamide, one tetracycline, two glycopeptides, five fluoroquinolones, and one oxazolidinone. The incidence of methicillin-resistant S. aureus (MRSA) was 63.4%, and the incidences of penicillin-intermediately resistant S. pneumoniae (PISP) and penicillin-resistant S. pneumoniae (PRSP) were 35.0% and 4.0%, respectively. Among H. influenzae, 21.2% of the strains were found to be β-lactamase- nonproducing ampicillin (ABPC)-intermediately resistant (BLNAI), 29.1% to be β-lactamase-nonproducing ABPC-resistant (BLNAR), and 4.8% to be β-lactamaseproducing ABPC-resistant (BLPAR) strains. The incidence of extended-spectrum β-lactamase-producing K. pneumoniae was 2.7% (2 of 74 strains). Three (2.1%) of the 143 P. aeruginosa strains were found to be metallo-β-lactamaseproducing, including 1 (0.7%) multidrug-resistant strain. Through the nationwide surveillance, we obtained fundamental antimicrobial susceptibility data of clinically relevant bacterial pathogens in adult RTI to various antibacterial agents. These data will be a useful reference for future periodic surveillance studies, as well as for investigations to control antimicrobial-resistant pathogens.

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