The function of argos in regulating cell fate decisions during drosophila eye and wing vein development

Kazunobu Sawamoto, Hideyuki Okano, Yoshitaka Kobayakawa, Shigeo Hayashi, Katsuhiko Mikoshiba, Teiichi Tanimura

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The Drosophila argos gene, which encodes a secreted protein with an EGF motif, is involved in several developmental processes regulating cell-cell interactions such as eye morphogenesis. Loss-of-function mutations in the argos gene cause an increase in the number of photoreceptor cells and cone cells, impaired retinal projections to the optic lobe, and the formation of extra veins. We show here that ubiquitously expressed argos product restored all these loss-of-function phenotypes. Overexpression of argos in the wild- type background resulted in the reduced number of photoreceptor cells, cone cells, and pigment cells, which are phenotypes opposite to those of the loss- of-function mutants. The argos gene is expressed in developing wing veins. Ubiquitous argos expression caused loss of veins in a dose-dependent manner. This phenotype was enhanced by the loss-of-function rhomboid mutation, implying the possibility that argos and rhomboid play key roles in a common pathway for normal wing vein formation. We propose that argos acts as an inhibitory signal for cellular differentiation in the developing eye and wing.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalDevelopmental Biology
Volume164
Issue number1
DOIs
Publication statusPublished - Jul 1994

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Retinal Cone Photoreceptor Cells
Drosophila
Veins
Phenotype
Genes
Mutation
Morphogenesis
Epidermal Growth Factor
Cell Communication
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

The function of argos in regulating cell fate decisions during drosophila eye and wing vein development. / Sawamoto, Kazunobu; Okano, Hideyuki; Kobayakawa, Yoshitaka; Hayashi, Shigeo; Mikoshiba, Katsuhiko; Tanimura, Teiichi.

In: Developmental Biology, Vol. 164, No. 1, 07.1994, p. 267-276.

Research output: Contribution to journalArticle

Sawamoto, Kazunobu ; Okano, Hideyuki ; Kobayakawa, Yoshitaka ; Hayashi, Shigeo ; Mikoshiba, Katsuhiko ; Tanimura, Teiichi. / The function of argos in regulating cell fate decisions during drosophila eye and wing vein development. In: Developmental Biology. 1994 ; Vol. 164, No. 1. pp. 267-276.
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