The function of glucagon-like peptide-1 in the mouse peripheral taste system

Shingo Takai, Ryusuke Yoshida, Keiko Nakano, Noriatsu Shigemura, Yuzo Ninomiya

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background Several studies have demonstrated that some gut peptides known to be important in energy metabolism are expressed in mouse taste bud cells. However, the functions of these peptides in taste cells are still largely unknown. In the gut, one of these peptides, glucagon-like peptide-1 (GLP-1), which is known as the insulinotropic gut peptide, is secreted from enteroendocrine L-cells, which express as many taste molecules as those on the tongue. These taste transduction molecules are suggested to be involved in GLP-1 secretion from L-cells in response to various nutrient stimuli. GLP-1 is reported to function as a neurotransmitter via activation of its receptors expressed on the vagus nerve, thereby regulating insulin secretion. Highlight Consistent with this evidence from the gastrointestinal tract, recent studies have demonstrated that GLP-1 is secreted from mouse taste cells in response to taste compounds such as sugars, artificial sweeteners, and long-chain fatty acids. GLP-1 secreted from taste cells may activate particular types of gustatory nerve fibers because they express GLP-1 receptors and respond to GLP-1 administered via the femoral vein. Conclusion GLP-1 released from taste cells may be involved in transmission of sweet and lipid signals, thereby impacting animalsfeeding behavior in response to these important nutrient factors.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
Journaljournal of oral biosciences
Volume58
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Glucagon-Like Peptide 1
Peptides
Nutrients
Sweetening Agents
Enteroendocrine Cells
Taste Buds
Molecules
Food
Vagus Nerve
Femoral Vein
Sugars
Neurotransmitter Agents
Nerve Fibers
Tongue
Energy Metabolism
Fatty Acids
Gastrointestinal Tract
Chemical activation
Insulin
Lipids

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The function of glucagon-like peptide-1 in the mouse peripheral taste system. / Takai, Shingo; Yoshida, Ryusuke; Nakano, Keiko; Shigemura, Noriatsu; Ninomiya, Yuzo.

In: journal of oral biosciences, Vol. 58, No. 1, 01.02.2016, p. 10-15.

Research output: Contribution to journalReview article

Takai, Shingo ; Yoshida, Ryusuke ; Nakano, Keiko ; Shigemura, Noriatsu ; Ninomiya, Yuzo. / The function of glucagon-like peptide-1 in the mouse peripheral taste system. In: journal of oral biosciences. 2016 ; Vol. 58, No. 1. pp. 10-15.
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