The glial perspective of autism spectrum disorders

Fares Zeidán-Chuliá, Alla B. Salmina, Natalia A. Malinovskaya, Mami Noda, Alexei Verkhratsky, José Cláudio Fonseca Moreira

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

The aetiology of autism spectrum disorders remains unclear although a growing number of associated genetic abnormalities and environmental factors have been discovered in recent decades. These advancements coincided with a remarkable increase in the comprehension of physiological functions and pathological potential of neuroglia in the central nervous system that led to a notion of fundamental contribution of glial cells into multiple neuropathologies, including neuropsychiatric and developmental disorders. Growing evidence indicates a role for deregulation of astroglial control over homeostasis and plastic potential of neural networks as well as microglial malfunction and neuroinflammatory response in the brains of autistic patients. In this review, we shall summarize the status and pathological potential of neuroglia and argue for neuroglial roots of autistic disorders.

Original languageEnglish
Pages (from-to)160-172
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume38
DOIs
Publication statusPublished - Jan 1 2014

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Neuroglia
Autistic Disorder
Plastics
Homeostasis
Central Nervous System
Brain
Autism Spectrum Disorder
Neuropathology

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Zeidán-Chuliá, F., Salmina, A. B., Malinovskaya, N. A., Noda, M., Verkhratsky, A., & Moreira, J. C. F. (2014). The glial perspective of autism spectrum disorders. Neuroscience and Biobehavioral Reviews, 38, 160-172. https://doi.org/10.1016/j.neubiorev.2013.11.008

The glial perspective of autism spectrum disorders. / Zeidán-Chuliá, Fares; Salmina, Alla B.; Malinovskaya, Natalia A.; Noda, Mami; Verkhratsky, Alexei; Moreira, José Cláudio Fonseca.

In: Neuroscience and Biobehavioral Reviews, Vol. 38, 01.01.2014, p. 160-172.

Research output: Contribution to journalReview article

Zeidán-Chuliá, F, Salmina, AB, Malinovskaya, NA, Noda, M, Verkhratsky, A & Moreira, JCF 2014, 'The glial perspective of autism spectrum disorders', Neuroscience and Biobehavioral Reviews, vol. 38, pp. 160-172. https://doi.org/10.1016/j.neubiorev.2013.11.008
Zeidán-Chuliá F, Salmina AB, Malinovskaya NA, Noda M, Verkhratsky A, Moreira JCF. The glial perspective of autism spectrum disorders. Neuroscience and Biobehavioral Reviews. 2014 Jan 1;38:160-172. https://doi.org/10.1016/j.neubiorev.2013.11.008
Zeidán-Chuliá, Fares ; Salmina, Alla B. ; Malinovskaya, Natalia A. ; Noda, Mami ; Verkhratsky, Alexei ; Moreira, José Cláudio Fonseca. / The glial perspective of autism spectrum disorders. In: Neuroscience and Biobehavioral Reviews. 2014 ; Vol. 38. pp. 160-172.
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