The grading of lymphovascular space invasion in endometrial carcinoma

Toru Hachisuga, Tsunehisa Kaku, Kouichi Fukuda, Fuyuki Eguchi, Makoto Emoto, Toshiharu Kamura, Tsuyoshi Iwasaka, Tatsuhiko Kawarabayashi, Hajime Sugimori, Mitsuru Mori

Research output: Contribution to journalArticle

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Abstract

BACKGROUND. This study was conducted to elucidate the prognostic significance of a three-grade system for lymphovascular space invasion (LVSI). METHODS. The prognostic significance of the grading of LVSI as compared with other pathologic variables was evaluated in a study of 303 Japanese women with endometrial carcinoma. The criteria for determining the grade of LVSI were as follows: none (no LVSI), mild (a focus of LVSI was recognized around a tumor), and severe (diffuse or multifocal LVSI were recognized around the tumor or in the myometrium regardless of the degree of myometrial invasion). Both univariate and multivariate regression analyses were performed. The effects of different surgical methods and adjuvant therapies on survival were also examined. RESULTS. A univariate survival analysis showed that survival significantly correlated with surgical stage, histologic grade, depth of myometrial invasion, LVSI, cervical invasion, ovarian metastasis, and tubal metastasis. Of the three grades of LVSI, survival showed the most difference between the mild and severe groups. In multivariate analysis, the highest correlation with survival was observed for LVSI (P = 0.0008). Lymph node metastasis was also significantly associated with LVSI (P = 0.0001). The correlation between histologic variables and survival was only slightly influenced by the differences in surgical methods and adjuvant therapies. CONCLUSIONS. The grading of LVSI was found to be an important histologic prognostic variable. The severe degree of LVSI also was found to be a good indicator of lymph node metastasis. It is therefore important to evaluate the grade of LVSI based on a histologic examination of at least one cut surface of the hysterectomy specimen that macroscopically shows the deepest myometrial invasion.

Original languageEnglish
Pages (from-to)2090-2097
Number of pages8
JournalCancer
Volume86
Issue number10
DOIs
Publication statusPublished - Nov 15 1999

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Endometrial Neoplasms
Survival
Neoplasm Metastasis
Multivariate Analysis
Lymph Nodes
Myometrium
Survival Analysis
Hysterectomy
Neoplasms
Regression Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Hachisuga, T., Kaku, T., Fukuda, K., Eguchi, F., Emoto, M., Kamura, T., ... Mori, M. (1999). The grading of lymphovascular space invasion in endometrial carcinoma. Cancer, 86(10), 2090-2097. https://doi.org/10.1002/(SICI)1097-0142(19991115)86:10<2090::AID-CNCR29>3.0.CO;2-7

The grading of lymphovascular space invasion in endometrial carcinoma. / Hachisuga, Toru; Kaku, Tsunehisa; Fukuda, Kouichi; Eguchi, Fuyuki; Emoto, Makoto; Kamura, Toshiharu; Iwasaka, Tsuyoshi; Kawarabayashi, Tatsuhiko; Sugimori, Hajime; Mori, Mitsuru.

In: Cancer, Vol. 86, No. 10, 15.11.1999, p. 2090-2097.

Research output: Contribution to journalArticle

Hachisuga, T, Kaku, T, Fukuda, K, Eguchi, F, Emoto, M, Kamura, T, Iwasaka, T, Kawarabayashi, T, Sugimori, H & Mori, M 1999, 'The grading of lymphovascular space invasion in endometrial carcinoma', Cancer, vol. 86, no. 10, pp. 2090-2097. https://doi.org/10.1002/(SICI)1097-0142(19991115)86:10<2090::AID-CNCR29>3.0.CO;2-7
Hachisuga, Toru ; Kaku, Tsunehisa ; Fukuda, Kouichi ; Eguchi, Fuyuki ; Emoto, Makoto ; Kamura, Toshiharu ; Iwasaka, Tsuyoshi ; Kawarabayashi, Tatsuhiko ; Sugimori, Hajime ; Mori, Mitsuru. / The grading of lymphovascular space invasion in endometrial carcinoma. In: Cancer. 1999 ; Vol. 86, No. 10. pp. 2090-2097.
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AU - Kaku, Tsunehisa

AU - Fukuda, Kouichi

AU - Eguchi, Fuyuki

AU - Emoto, Makoto

AU - Kamura, Toshiharu

AU - Iwasaka, Tsuyoshi

AU - Kawarabayashi, Tatsuhiko

AU - Sugimori, Hajime

AU - Mori, Mitsuru

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N2 - BACKGROUND. This study was conducted to elucidate the prognostic significance of a three-grade system for lymphovascular space invasion (LVSI). METHODS. The prognostic significance of the grading of LVSI as compared with other pathologic variables was evaluated in a study of 303 Japanese women with endometrial carcinoma. The criteria for determining the grade of LVSI were as follows: none (no LVSI), mild (a focus of LVSI was recognized around a tumor), and severe (diffuse or multifocal LVSI were recognized around the tumor or in the myometrium regardless of the degree of myometrial invasion). Both univariate and multivariate regression analyses were performed. The effects of different surgical methods and adjuvant therapies on survival were also examined. RESULTS. A univariate survival analysis showed that survival significantly correlated with surgical stage, histologic grade, depth of myometrial invasion, LVSI, cervical invasion, ovarian metastasis, and tubal metastasis. Of the three grades of LVSI, survival showed the most difference between the mild and severe groups. In multivariate analysis, the highest correlation with survival was observed for LVSI (P = 0.0008). Lymph node metastasis was also significantly associated with LVSI (P = 0.0001). The correlation between histologic variables and survival was only slightly influenced by the differences in surgical methods and adjuvant therapies. CONCLUSIONS. The grading of LVSI was found to be an important histologic prognostic variable. The severe degree of LVSI also was found to be a good indicator of lymph node metastasis. It is therefore important to evaluate the grade of LVSI based on a histologic examination of at least one cut surface of the hysterectomy specimen that macroscopically shows the deepest myometrial invasion.

AB - BACKGROUND. This study was conducted to elucidate the prognostic significance of a three-grade system for lymphovascular space invasion (LVSI). METHODS. The prognostic significance of the grading of LVSI as compared with other pathologic variables was evaluated in a study of 303 Japanese women with endometrial carcinoma. The criteria for determining the grade of LVSI were as follows: none (no LVSI), mild (a focus of LVSI was recognized around a tumor), and severe (diffuse or multifocal LVSI were recognized around the tumor or in the myometrium regardless of the degree of myometrial invasion). Both univariate and multivariate regression analyses were performed. The effects of different surgical methods and adjuvant therapies on survival were also examined. RESULTS. A univariate survival analysis showed that survival significantly correlated with surgical stage, histologic grade, depth of myometrial invasion, LVSI, cervical invasion, ovarian metastasis, and tubal metastasis. Of the three grades of LVSI, survival showed the most difference between the mild and severe groups. In multivariate analysis, the highest correlation with survival was observed for LVSI (P = 0.0008). Lymph node metastasis was also significantly associated with LVSI (P = 0.0001). The correlation between histologic variables and survival was only slightly influenced by the differences in surgical methods and adjuvant therapies. CONCLUSIONS. The grading of LVSI was found to be an important histologic prognostic variable. The severe degree of LVSI also was found to be a good indicator of lymph node metastasis. It is therefore important to evaluate the grade of LVSI based on a histologic examination of at least one cut surface of the hysterectomy specimen that macroscopically shows the deepest myometrial invasion.

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