The graft bending angle can affect early graft healing after anterior cruciate ligament reconstruction: In vivo analysis with 2 years' follow-up

Yasutaka Tashiro, Tom Gale, Vani Sundaram, Kanto Nagai, James J. Irrgang, William Anderst, Yasuharu Nakashima, Scott Tashman, Freddie H. Fu

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Abstract

Background: A high graft bending angle (GBA) after anterior cruciate ligament (ACL) reconstruction has been suggested to cause stress on the graft. Nevertheless, evidence about its effect on graft healing in vivo is limited. Hypothesis: The signal intensity on magnetic resonance imaging (MRI) would be higher in the proximal region of the ACL graft, and higher signals would be correlated to a higher GBA. Study Design: Descriptive laboratory study. Methods: Anatomic single-bundle ACL reconstruction was performed on 24 patients (mean age, 20 ± 4 years) using the transportal technique. A quadriceps tendon autograft with a bone plug was harvested. To evaluate graft healing, the signal/noise quotient (SNQ) was measured in 3 regions of interest (ROIs) of the proximal, midsubstance, and distal ACL graft using high-resolution MRI (0.45 × 0.45 × 0.70 mm), with decreased signals suggesting improved healing. Dynamic knee motion was examined during treadmill walking and running to assess the in vivo GBA. The GBA was calculated from the 3-dimensional angle between the graft and femoral tunnel vectors at each motion frame, based on tibiofemoral kinematics determined from dynamic stereo X-ray analysis. Graft healing and GBAs were assessed at 6 and 24 months postoperatively. Repeated-measures analysis of variance was used to compare the SNQ in the 3 ROIs at 2 time points. Pearson correlations were used to analyze the relationship between the SNQ and mean GBA during 0% to 15% of the gait cycle. Results: The SNQ of the ACL graft in the proximal region was significantly higher than in the midsubstance (P =.022) and distal regions (P <.001) at 6 months. The SNQ in the proximal region was highly correlated with the GBA during standing (R = 0.64, P <.001), walking (R = 0.65, P =.002), and running (R = 0.54, P =.015) but not in the other regions. At 24 months, signals in the proximal and midsubstance regions decreased significantly compared with 6 months (P <.001 and P =.008, respectively), with no difference across the graft area. Conclusion: The signal intensity was highest in the proximal region and lowest in the distal region of the reconstructed graft at 6 months postoperatively. A steep GBA was significantly correlated with high signal intensities of the proximal graft in this early period. A steep GBA may negatively affect proximal graft healing after ACL reconstruction.

Original languageEnglish
Pages (from-to)1829-1836
Number of pages8
JournalAmerican Journal of Sports Medicine
Volume45
Issue number8
DOIs
Publication statusPublished - Jul 1 2017

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Anterior Cruciate Ligament Reconstruction
Transplants
Noise
Anterior Cruciate Ligament
Running
Walking
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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The graft bending angle can affect early graft healing after anterior cruciate ligament reconstruction : In vivo analysis with 2 years' follow-up. / Tashiro, Yasutaka; Gale, Tom; Sundaram, Vani; Nagai, Kanto; Irrgang, James J.; Anderst, William; Nakashima, Yasuharu; Tashman, Scott; Fu, Freddie H.

In: American Journal of Sports Medicine, Vol. 45, No. 8, 01.07.2017, p. 1829-1836.

Research output: Contribution to journalArticle

Tashiro, Yasutaka ; Gale, Tom ; Sundaram, Vani ; Nagai, Kanto ; Irrgang, James J. ; Anderst, William ; Nakashima, Yasuharu ; Tashman, Scott ; Fu, Freddie H. / The graft bending angle can affect early graft healing after anterior cruciate ligament reconstruction : In vivo analysis with 2 years' follow-up. In: American Journal of Sports Medicine. 2017 ; Vol. 45, No. 8. pp. 1829-1836.
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abstract = "Background: A high graft bending angle (GBA) after anterior cruciate ligament (ACL) reconstruction has been suggested to cause stress on the graft. Nevertheless, evidence about its effect on graft healing in vivo is limited. Hypothesis: The signal intensity on magnetic resonance imaging (MRI) would be higher in the proximal region of the ACL graft, and higher signals would be correlated to a higher GBA. Study Design: Descriptive laboratory study. Methods: Anatomic single-bundle ACL reconstruction was performed on 24 patients (mean age, 20 ± 4 years) using the transportal technique. A quadriceps tendon autograft with a bone plug was harvested. To evaluate graft healing, the signal/noise quotient (SNQ) was measured in 3 regions of interest (ROIs) of the proximal, midsubstance, and distal ACL graft using high-resolution MRI (0.45 × 0.45 × 0.70 mm), with decreased signals suggesting improved healing. Dynamic knee motion was examined during treadmill walking and running to assess the in vivo GBA. The GBA was calculated from the 3-dimensional angle between the graft and femoral tunnel vectors at each motion frame, based on tibiofemoral kinematics determined from dynamic stereo X-ray analysis. Graft healing and GBAs were assessed at 6 and 24 months postoperatively. Repeated-measures analysis of variance was used to compare the SNQ in the 3 ROIs at 2 time points. Pearson correlations were used to analyze the relationship between the SNQ and mean GBA during 0{\%} to 15{\%} of the gait cycle. Results: The SNQ of the ACL graft in the proximal region was significantly higher than in the midsubstance (P =.022) and distal regions (P <.001) at 6 months. The SNQ in the proximal region was highly correlated with the GBA during standing (R = 0.64, P <.001), walking (R = 0.65, P =.002), and running (R = 0.54, P =.015) but not in the other regions. At 24 months, signals in the proximal and midsubstance regions decreased significantly compared with 6 months (P <.001 and P =.008, respectively), with no difference across the graft area. Conclusion: The signal intensity was highest in the proximal region and lowest in the distal region of the reconstructed graft at 6 months postoperatively. A steep GBA was significantly correlated with high signal intensities of the proximal graft in this early period. A steep GBA may negatively affect proximal graft healing after ACL reconstruction.",
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T1 - The graft bending angle can affect early graft healing after anterior cruciate ligament reconstruction

T2 - In vivo analysis with 2 years' follow-up

AU - Tashiro, Yasutaka

AU - Gale, Tom

AU - Sundaram, Vani

AU - Nagai, Kanto

AU - Irrgang, James J.

AU - Anderst, William

AU - Nakashima, Yasuharu

AU - Tashman, Scott

AU - Fu, Freddie H.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background: A high graft bending angle (GBA) after anterior cruciate ligament (ACL) reconstruction has been suggested to cause stress on the graft. Nevertheless, evidence about its effect on graft healing in vivo is limited. Hypothesis: The signal intensity on magnetic resonance imaging (MRI) would be higher in the proximal region of the ACL graft, and higher signals would be correlated to a higher GBA. Study Design: Descriptive laboratory study. Methods: Anatomic single-bundle ACL reconstruction was performed on 24 patients (mean age, 20 ± 4 years) using the transportal technique. A quadriceps tendon autograft with a bone plug was harvested. To evaluate graft healing, the signal/noise quotient (SNQ) was measured in 3 regions of interest (ROIs) of the proximal, midsubstance, and distal ACL graft using high-resolution MRI (0.45 × 0.45 × 0.70 mm), with decreased signals suggesting improved healing. Dynamic knee motion was examined during treadmill walking and running to assess the in vivo GBA. The GBA was calculated from the 3-dimensional angle between the graft and femoral tunnel vectors at each motion frame, based on tibiofemoral kinematics determined from dynamic stereo X-ray analysis. Graft healing and GBAs were assessed at 6 and 24 months postoperatively. Repeated-measures analysis of variance was used to compare the SNQ in the 3 ROIs at 2 time points. Pearson correlations were used to analyze the relationship between the SNQ and mean GBA during 0% to 15% of the gait cycle. Results: The SNQ of the ACL graft in the proximal region was significantly higher than in the midsubstance (P =.022) and distal regions (P <.001) at 6 months. The SNQ in the proximal region was highly correlated with the GBA during standing (R = 0.64, P <.001), walking (R = 0.65, P =.002), and running (R = 0.54, P =.015) but not in the other regions. At 24 months, signals in the proximal and midsubstance regions decreased significantly compared with 6 months (P <.001 and P =.008, respectively), with no difference across the graft area. Conclusion: The signal intensity was highest in the proximal region and lowest in the distal region of the reconstructed graft at 6 months postoperatively. A steep GBA was significantly correlated with high signal intensities of the proximal graft in this early period. A steep GBA may negatively affect proximal graft healing after ACL reconstruction.

AB - Background: A high graft bending angle (GBA) after anterior cruciate ligament (ACL) reconstruction has been suggested to cause stress on the graft. Nevertheless, evidence about its effect on graft healing in vivo is limited. Hypothesis: The signal intensity on magnetic resonance imaging (MRI) would be higher in the proximal region of the ACL graft, and higher signals would be correlated to a higher GBA. Study Design: Descriptive laboratory study. Methods: Anatomic single-bundle ACL reconstruction was performed on 24 patients (mean age, 20 ± 4 years) using the transportal technique. A quadriceps tendon autograft with a bone plug was harvested. To evaluate graft healing, the signal/noise quotient (SNQ) was measured in 3 regions of interest (ROIs) of the proximal, midsubstance, and distal ACL graft using high-resolution MRI (0.45 × 0.45 × 0.70 mm), with decreased signals suggesting improved healing. Dynamic knee motion was examined during treadmill walking and running to assess the in vivo GBA. The GBA was calculated from the 3-dimensional angle between the graft and femoral tunnel vectors at each motion frame, based on tibiofemoral kinematics determined from dynamic stereo X-ray analysis. Graft healing and GBAs were assessed at 6 and 24 months postoperatively. Repeated-measures analysis of variance was used to compare the SNQ in the 3 ROIs at 2 time points. Pearson correlations were used to analyze the relationship between the SNQ and mean GBA during 0% to 15% of the gait cycle. Results: The SNQ of the ACL graft in the proximal region was significantly higher than in the midsubstance (P =.022) and distal regions (P <.001) at 6 months. The SNQ in the proximal region was highly correlated with the GBA during standing (R = 0.64, P <.001), walking (R = 0.65, P =.002), and running (R = 0.54, P =.015) but not in the other regions. At 24 months, signals in the proximal and midsubstance regions decreased significantly compared with 6 months (P <.001 and P =.008, respectively), with no difference across the graft area. Conclusion: The signal intensity was highest in the proximal region and lowest in the distal region of the reconstructed graft at 6 months postoperatively. A steep GBA was significantly correlated with high signal intensities of the proximal graft in this early period. A steep GBA may negatively affect proximal graft healing after ACL reconstruction.

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