The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis

Masatake Tanaka, Yasuko Iwakiri

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues.

Original languageEnglish
Pages (from-to)733-749
Number of pages17
JournalCMGH
Volume2
Issue number6
DOIs
Publication statusPublished - Nov 1 2016
Externally publishedYes

Fingerprint

Lymphangiogenesis
Lymphatic System
Blood Vessels
Liver
Genetically Modified Animals
Lymphatic Vessels
Cell Separation
Homeostasis
Endothelial Cells
Animal Models
Maintenance
Research

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

The Hepatic Lymphatic Vascular System : Structure, Function, Markers, and Lymphangiogenesis. / Tanaka, Masatake; Iwakiri, Yasuko.

In: CMGH, Vol. 2, No. 6, 01.11.2016, p. 733-749.

Research output: Contribution to journalReview article

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