The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

Gerald Siu, Stephen P. Clark, Yasunobu Yoshikai, Marie Malissen, Yusuke Yanagi, Erich Strauss, Tak W. Mak, Leroy Hood

Research output: Contribution to journalArticlepeer-review

182 Citations (Scopus)

Abstract

A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.

Original languageEnglish
Pages (from-to)393-401
Number of pages9
JournalCell
Volume37
Issue number2
DOIs
Publication statusPublished - Jun 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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