TY - JOUR
T1 - The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene
AU - Siu, Gerald
AU - Clark, Stephen P.
AU - Yoshikai, Yasunobu
AU - Malissen, Marie
AU - Yanagi, Yusuke
AU - Strauss, Erich
AU - Mak, Tak W.
AU - Hood, Leroy
PY - 1984/6
Y1 - 1984/6
N2 - A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.
AB - A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.
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U2 - 10.1016/0092-8674(84)90369-6
DO - 10.1016/0092-8674(84)90369-6
M3 - Article
C2 - 6202421
AN - SCOPUS:0021195875
VL - 37
SP - 393
EP - 401
JO - Cell
JF - Cell
SN - 0092-8674
IS - 2
ER -