The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

Gerald Siu; Stephen P. Clark; Yasunobu Yoshikai; Marie Malissen; Yusuke Yanagi; Erich Strauss; Tak W. Mak; Leroy Hood

doi:10.1016/0092-8674(84)90369-6

The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene

Gerald Siu, Stephen P. Clark, Yasunobu Yoshikai, Marie Malissen, Yusuke Yanagi, Erich Strauss, Tak W. Mak, Leroy Hood

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

Abstract

A cDNA clone YT35, synthesized from poly(A)⁺ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.

Original language	English
Pages (from-to)	393-401
Number of pages	9
Journal	Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/0092-8674(84)90369-6
Publication status	Published - Jun 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. / Siu, Gerald; Clark, Stephen P.; Yoshikai, Yasunobu; Malissen, Marie; Yanagi, Yusuke; Strauss, Erich; Mak, Tak W.; Hood, Leroy.

In: Cell, Vol. 37, No. 2, 06.1984, p. 393-401.

Research output: Contribution to journal › Article › peer-review

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abstract = "A cDNA clone YT35, synthesized from poly(A)+ RNA of the human T cell tumor Molt 3, exhibits homology to the variable (V), joining (J), and constant (C) regions of immunoglobulin genes. We have isolated and sequenced the germ-line V and J gene segment counterparts to YT35 from a human cosmid library, and these failed to encode 14 nucleotides of the cDNA clone between the V and J regions. We postulate that these 14 nucleotides are encoded by a third gene segment analogous to the diversity (D) gene segments of immunoglobulin heavy chain genes. This T cell antigen receptor V gene appears to be assembled from three gene segments, V, D, and J, and accordingly most closely resembles immunoglobulin heavy chain V genes.",

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