The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules

Shinobu Yasuo, Horst Werner Korf

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Located between the median eminence, the portal vessels, and the pars distalis (PD) of the hypophysis, the hypophysial pars tuberalis (PT) is an important center for transmission of photoperiodic information to neuroendocrine circuits involved in the control of reproduction, metabolism and behavior. Despite enormous and long lasting efforts, output pathways and messenger molecules from the PT have been unraveled only recently. Most interestingly, the PT sends its signals in two directions: via a " retrograde" pathway to the hypothalamus and via an " anterograde" pathway to the PD. TSH has been identified as a messenger of the " retrograde" pathway. As discovered in Japanese quail, TSH triggers molecular cascades mediating thyroid hormone conversion in the mediobasal hypothalamus (MBH) to activate the gonadal axis. These molecular mechanisms are conserved in photoperiodic mammals, and even in non-photoperiodic laboratory mice. The search for molecules of the " anterograde" pathway was for a long time focused on PT-specific neuropeptides, the so-called " tuberalins" The discovery of a PT-intrinsic endocannabinoid system in hamsters which is regulated by the photoperiod provides strong experimental evidence that the PT also synthesizes lipidergic messengers. To date, 2-arachidonoylglycerol (2-AG) appears as the most important lipidergic messenger from the PT. The primary target of 2-AG, the cannabinoid receptor 1 (CB1) is expressed in the hamster PD. A PT-intrinsic endocannabinoid system also exists in man and CB1 receptors are demonstrated in ACTH-producing cells and folliculo-stellate cells of the human PD. These data lend support to the hypothesis that endocannabinoids function as messengers of the anterograde pathway.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume172
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

Fingerprint

Endocannabinoids
hypothalamus
hamsters
Cannabinoid Receptors
Cricetinae
Hypothalamus
pituitary gland
neuropeptides
corticotropin
thyroid hormones
Coturnix
Median Eminence
photoperiod
Photoperiod
Pituitary Gland
cells
mammals
Neuropeptides
Thyroid Hormones
Adrenocorticotropic Hormone

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules. / Yasuo, Shinobu; Korf, Horst Werner.

In: General and Comparative Endocrinology, Vol. 172, No. 1, 01.01.2011, p. 15-22.

Research output: Contribution to journalReview article

@article{47a2b0a4539a425484bf6703471600cd,
title = "The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules",
abstract = "Located between the median eminence, the portal vessels, and the pars distalis (PD) of the hypophysis, the hypophysial pars tuberalis (PT) is an important center for transmission of photoperiodic information to neuroendocrine circuits involved in the control of reproduction, metabolism and behavior. Despite enormous and long lasting efforts, output pathways and messenger molecules from the PT have been unraveled only recently. Most interestingly, the PT sends its signals in two directions: via a {"} retrograde{"} pathway to the hypothalamus and via an {"} anterograde{"} pathway to the PD. TSH has been identified as a messenger of the {"} retrograde{"} pathway. As discovered in Japanese quail, TSH triggers molecular cascades mediating thyroid hormone conversion in the mediobasal hypothalamus (MBH) to activate the gonadal axis. These molecular mechanisms are conserved in photoperiodic mammals, and even in non-photoperiodic laboratory mice. The search for molecules of the {"} anterograde{"} pathway was for a long time focused on PT-specific neuropeptides, the so-called {"} tuberalins{"} The discovery of a PT-intrinsic endocannabinoid system in hamsters which is regulated by the photoperiod provides strong experimental evidence that the PT also synthesizes lipidergic messengers. To date, 2-arachidonoylglycerol (2-AG) appears as the most important lipidergic messenger from the PT. The primary target of 2-AG, the cannabinoid receptor 1 (CB1) is expressed in the hamster PD. A PT-intrinsic endocannabinoid system also exists in man and CB1 receptors are demonstrated in ACTH-producing cells and folliculo-stellate cells of the human PD. These data lend support to the hypothesis that endocannabinoids function as messengers of the anterograde pathway.",
author = "Shinobu Yasuo and Korf, {Horst Werner}",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.ygcen.2010.11.006",
language = "English",
volume = "172",
pages = "15--22",
journal = "General and Comparative Endocrinology",
issn = "0016-6480",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The hypophysial pars tuberalis transduces photoperiodic signals via multiple pathways and messenger molecules

AU - Yasuo, Shinobu

AU - Korf, Horst Werner

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Located between the median eminence, the portal vessels, and the pars distalis (PD) of the hypophysis, the hypophysial pars tuberalis (PT) is an important center for transmission of photoperiodic information to neuroendocrine circuits involved in the control of reproduction, metabolism and behavior. Despite enormous and long lasting efforts, output pathways and messenger molecules from the PT have been unraveled only recently. Most interestingly, the PT sends its signals in two directions: via a " retrograde" pathway to the hypothalamus and via an " anterograde" pathway to the PD. TSH has been identified as a messenger of the " retrograde" pathway. As discovered in Japanese quail, TSH triggers molecular cascades mediating thyroid hormone conversion in the mediobasal hypothalamus (MBH) to activate the gonadal axis. These molecular mechanisms are conserved in photoperiodic mammals, and even in non-photoperiodic laboratory mice. The search for molecules of the " anterograde" pathway was for a long time focused on PT-specific neuropeptides, the so-called " tuberalins" The discovery of a PT-intrinsic endocannabinoid system in hamsters which is regulated by the photoperiod provides strong experimental evidence that the PT also synthesizes lipidergic messengers. To date, 2-arachidonoylglycerol (2-AG) appears as the most important lipidergic messenger from the PT. The primary target of 2-AG, the cannabinoid receptor 1 (CB1) is expressed in the hamster PD. A PT-intrinsic endocannabinoid system also exists in man and CB1 receptors are demonstrated in ACTH-producing cells and folliculo-stellate cells of the human PD. These data lend support to the hypothesis that endocannabinoids function as messengers of the anterograde pathway.

AB - Located between the median eminence, the portal vessels, and the pars distalis (PD) of the hypophysis, the hypophysial pars tuberalis (PT) is an important center for transmission of photoperiodic information to neuroendocrine circuits involved in the control of reproduction, metabolism and behavior. Despite enormous and long lasting efforts, output pathways and messenger molecules from the PT have been unraveled only recently. Most interestingly, the PT sends its signals in two directions: via a " retrograde" pathway to the hypothalamus and via an " anterograde" pathway to the PD. TSH has been identified as a messenger of the " retrograde" pathway. As discovered in Japanese quail, TSH triggers molecular cascades mediating thyroid hormone conversion in the mediobasal hypothalamus (MBH) to activate the gonadal axis. These molecular mechanisms are conserved in photoperiodic mammals, and even in non-photoperiodic laboratory mice. The search for molecules of the " anterograde" pathway was for a long time focused on PT-specific neuropeptides, the so-called " tuberalins" The discovery of a PT-intrinsic endocannabinoid system in hamsters which is regulated by the photoperiod provides strong experimental evidence that the PT also synthesizes lipidergic messengers. To date, 2-arachidonoylglycerol (2-AG) appears as the most important lipidergic messenger from the PT. The primary target of 2-AG, the cannabinoid receptor 1 (CB1) is expressed in the hamster PD. A PT-intrinsic endocannabinoid system also exists in man and CB1 receptors are demonstrated in ACTH-producing cells and folliculo-stellate cells of the human PD. These data lend support to the hypothesis that endocannabinoids function as messengers of the anterograde pathway.

UR - http://www.scopus.com/inward/record.url?scp=79955718733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955718733&partnerID=8YFLogxK

U2 - 10.1016/j.ygcen.2010.11.006

DO - 10.1016/j.ygcen.2010.11.006

M3 - Review article

C2 - 21078321

AN - SCOPUS:79955718733

VL - 172

SP - 15

EP - 22

JO - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

IS - 1

ER -