The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks

Tetsuya Tachibana, Keiko Hirofuji, Mako Matsumoto, Mitsuhiro Furuse, Shin Hasegawa, Fumiaki Yoshizawa, Kunio Sugahara

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13 Citations (Scopus)

Abstract

The present study was carried out to investigate whether the hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 (GLP-1) in chicks. To examine this, Fos expression in the chick hypothalamus were immunohistochemically detected after intracerebroventricular (ICV) injection of 30-pmol GLP-1. ICV injection of GLP-1 stimulated the expression of Fos-like immunoreactive (FLI) cells in the ventromedial hypothalamic nucleus (VMN). When 15-pmol GLP-1 was directly injected into the chick VMN, the chick's food intake was significantly decreased compared with the control treatment. Microinjection of GLP-1 into the (LHA) also inhibited feeding in chicks, although ICV injection of GLP-1 did not stimulate FLI expression in the brain area. These results suggest that VMN and some brain regions are involved in the anorexic effect of GLP-1 in chicks.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume137
Issue number1
DOIs
Publication statusPublished - Jan 2004

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology

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