TY - JOUR
T1 - The IASLC/ITMIG thymic epithelial tumors staging project
T2 - Proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors
AU - Nicholson, Andrew G.
AU - Detterbeck, Frank C.
AU - Marino, Mirella
AU - Kim, Jhingook
AU - Stratton, Kelly
AU - Giroux, Dorothy
AU - Asamura, Hisao
AU - Crowley, John
AU - Falkson, Conrad
AU - Filosso, Pier Luigi
AU - Giaccone, Giuseppe
AU - Huang, James
AU - Kondo, Kazuya
AU - Lucchi, Marco
AU - Marom, Edith M.
AU - Okumura, Meinoshin
AU - Ruffini, Enrico
AU - Van Schil, Paul
AU - Goldstraw, Peter
AU - Rami-Porta, Ramón
AU - Ball, David
AU - Beer, David
AU - Beyruti, Ricardo
AU - Bolejack, Vanessa
AU - Chansky, Kari
AU - Eberhardt, Wilfried Ernst Erich
AU - Edwards, John
AU - Galateau-Sallé, Françoise
AU - Gleeson, Fergus
AU - Groome, Patti
AU - Kennedy, Catherine
AU - Kingsbury, Laura
AU - Kim, Young Tae
AU - Kondo, Haruhiko
AU - Krasnik, Mark
AU - Kubota, Kaoru
AU - Lerut, Antoon
AU - Lyons, Gustavo
AU - Van Meerbeeck, Jan
AU - Mitchell, Alan
AU - Nakano, Takashi
AU - Nowak, Anna
AU - Peake, Michael
AU - Rice, Thomas
AU - Rosenzweig, Kenneth
AU - Rusch, Valerie
AU - Saijo, Nagahiro
AU - Sculier, Jean Paul
AU - Shemanski, Lynn
AU - Suzuki, Kenji
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.
AB - Despite longstanding recognition of thymic epithelial neoplasms, there is no official American Joint Committee on Cancer/ Union for International Cancer Control stage classification. This article summarizes proposals for classification of the T component of stage classification for use in the 8th edition of the tumor, node, metastasis classification for malignant tumors. This represents the output of the International Association for the Study of Lung Cancer and the International Thymic Malignancies Interest Group Staging and Prognostics Factor Committee, which assembled and analyzed a worldwide database of 10,808 patients with thymic malignancies from 105 sites. The committee proposes division of the T component into four categories, representing levels of invasion. T1 includes tumors localized to the thymus and anterior mediastinal fat, regardless of capsular invasion, up to and including infiltration through the mediastinal pleura. Invasion of the pericardium is designated as T2. T3 includes tumors with direct involvement of a group of mediastinal structures either singly or in combination: lung, brachiocephalic vein, superior vena cava, chest wall, and phrenic nerve. Invasion of more central structures constitutes T4: aorta and arch vessels, intrapericardial pulmonary artery, myocardium, trachea, and esophagus. Size did not emerge as a useful descriptor for stage classification. This classification of T categories, combined with a classification of N and M categories, provides a basis for a robust tumor, node, metastasis classification system for the 8th edition of American Joint Committee on Cancer/Union for International Cancer Control stage classification.
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U2 - 10.1097/JTO.0000000000000303
DO - 10.1097/JTO.0000000000000303
M3 - Article
C2 - 25396315
AN - SCOPUS:84921747900
VL - 9
SP - S73-S80
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 9
ER -