The IL-13–OVOL1–FLG axis in atopic dermatitis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Dugarmaa Ulzii, Yen Hai Vu, Makiko Kido-Nakahara, Takeshi Nakahara, Masutaka Furue

Research output: Contribution to journalReview article

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Abstract

Despite sharing interleukin-4 receptor α (IL-4Rα) in their signaling cascades, IL-4 and IL-13 have different functions in atopic inflammation. IL-13 preferentially participates in the peripheral tissues because tissue-resident group 2 innate lymphoid cells produce IL-13 but not IL-4. In contrast, lymph node T follicular helper cells express IL-4 but not IL-13 to regulate B-cell immunity. The dominant microenvironment of IL-13 is evident in the lesional skin of atopic dermatitis (AD). The IL-13-rich local milieu causes barrier dysfunction by down-regulating the OVOL1–filaggrin (FLG) axis and up-regulating the periostin–IL-24 axis. Genome-wide association studies also point to the crucial involvement of the IL-13, OVOL1 and FLG genes in the pathogenesis of AD. Biologics targeting IL-13, such as the anti-IL-4Rα antibody dupilumab and the anti-IL-13 antibody tralokinumab, successfully improve AD lesions and further highlight the importance of IL-13 in the pathogenesis of AD.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalImmunology
Volume158
Issue number4
DOIs
Publication statusPublished - Dec 1 2019

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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