The impact of chronic imipramine treatment on amino acid concentrations in the hippocampus of mice

Mao Nagasawa, Tatsuro Murakami, Shozo Tomonaga, Mitsuhiro Furuse

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The relationship between antidepressants and monoamine concentrations in the brain has been well investigated, but few studies have investigated the relationship between antidepressants and amino acid concentrations in the brain. The purpose of the present study was therefore to investigate the effect of the chronic antidepressant imipramine on amino acid and monoamine concentrations in the mouse brain and plasma. Chronic imipramine treatment decreased the concentration of 5-hydroxyindoleaceticacid/ 5-hydroxytryptamine in the cerebral cortex and increased that of norepinephrine (NE) in the hippocampus. Since these changes were conspicuous effects of the antidepressant, we concluded that imipramine acts on the central nervous system. No change in amino acid concentrations in plasma was induced by chronic imipramine treatment, but several changes were confirmed in the cerebral cortex, the hypothalamus and the hippocampus. Chronic imipramine treatment caused increases in L-methionine, L-tyrosine, and L-lysine in the cerebral cortex, and an increase in L-aspartate in the hypothalamus. Contrary to this, the concentrations of L-aspartate, L-serine, L-asparagine, glycine, L-glutamine, gammaaminobutyric acid, L-threonine, L-arginine, L-proline, L-valine, and L-methionine in the hippocampus were decreased by chronic imipramine treatment. The present results demonstrate that the metabolism of several amino acids in the brain, but not of those in plasma, was altered by chronic imipramine treatment. The findings in the present study may help to further elucidate the relationship between amino acids and the effects and side effects of antidepressants.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalNutritional Neuroscience
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 1 2012

Fingerprint

Imipramine
Hippocampus
Antidepressive Agents
Amino Acids
Cerebral Cortex
Brain
Aspartic Acid
Methionine
Hypothalamus
Asparagine
Valine
Threonine
Glutamine
Proline
Glycine
Serine
Lysine
Tyrosine
Arginine
Serotonin

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

The impact of chronic imipramine treatment on amino acid concentrations in the hippocampus of mice. / Nagasawa, Mao; Murakami, Tatsuro; Tomonaga, Shozo; Furuse, Mitsuhiro.

In: Nutritional Neuroscience, Vol. 15, No. 5, 01.09.2012, p. 26-33.

Research output: Contribution to journalArticle

Nagasawa, Mao ; Murakami, Tatsuro ; Tomonaga, Shozo ; Furuse, Mitsuhiro. / The impact of chronic imipramine treatment on amino acid concentrations in the hippocampus of mice. In: Nutritional Neuroscience. 2012 ; Vol. 15, No. 5. pp. 26-33.
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