The impact of donor age on living donor liver transplantation

Toru Ikegami, T. Nishizaki, K. Yanaga, M. Shimada, K. Kishikawa, K. Nomoto, H. Uchiyama, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

Background. The impact of the age of the donor on the outcome of living related liver transplantation is yet to be clarified. Methods. During October 14, 1996 and December 20, 1999, 34 living related liver transplantations were performed. Of these, 26 cases were performed using the extended left lobe graft, which were classified into three groups; younger donor group (group Y, donor age <30, n=7), middle-aged donor group (group M, 30≤donor age <50, n=13), and older donor group (group O, donor age<50, n=6). Early allograft function and regeneration were compared between these groups. Results. There was no difference in standard liver volume, and predicted or harvested graft size between the three groups. Although serum transaminase and total bilirubin levels within postoperative day 7 were not different between the groups, the prothrombin time on postoperative day 3 was significantly longer in group O than in group Y. One week after transplantation, group Y had significantly greater graft/standard liver volume ratio than group O, and greater graft volume than group M and O. One month after transplantation, however, there was no significant difference in such graft size parameters between the groups. Graft and patient survival were comparable between the three groups. Conclusion. Although function and regeneration of the allografts from older donors in living donor liver transplantation is worse than those of their younger counterparts, the outcome is not affected by the age of the liver.

Original languageEnglish
Pages (from-to)1703-1707
Number of pages5
JournalTransplantation
Volume70
Issue number12
DOIs
Publication statusPublished - Dec 27 2000

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Living Donors
Liver Transplantation
Tissue Donors
Transplants
Allografts
Regeneration
Liver
Transplantation
Prothrombin Time
Graft Survival
Transaminases
Bilirubin
Serum

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Ikegami, T., Nishizaki, T., Yanaga, K., Shimada, M., Kishikawa, K., Nomoto, K., ... Sugimachi, K. (2000). The impact of donor age on living donor liver transplantation. Transplantation, 70(12), 1703-1707. https://doi.org/10.1097/00007890-200012270-00007

The impact of donor age on living donor liver transplantation. / Ikegami, Toru; Nishizaki, T.; Yanaga, K.; Shimada, M.; Kishikawa, K.; Nomoto, K.; Uchiyama, H.; Sugimachi, K.

In: Transplantation, Vol. 70, No. 12, 27.12.2000, p. 1703-1707.

Research output: Contribution to journalArticle

Ikegami, T, Nishizaki, T, Yanaga, K, Shimada, M, Kishikawa, K, Nomoto, K, Uchiyama, H & Sugimachi, K 2000, 'The impact of donor age on living donor liver transplantation', Transplantation, vol. 70, no. 12, pp. 1703-1707. https://doi.org/10.1097/00007890-200012270-00007
Ikegami T, Nishizaki T, Yanaga K, Shimada M, Kishikawa K, Nomoto K et al. The impact of donor age on living donor liver transplantation. Transplantation. 2000 Dec 27;70(12):1703-1707. https://doi.org/10.1097/00007890-200012270-00007
Ikegami, Toru ; Nishizaki, T. ; Yanaga, K. ; Shimada, M. ; Kishikawa, K. ; Nomoto, K. ; Uchiyama, H. ; Sugimachi, K. / The impact of donor age on living donor liver transplantation. In: Transplantation. 2000 ; Vol. 70, No. 12. pp. 1703-1707.
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