The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation: Significant lessons from a dual graft case

T. Motomura, A. Taketomi, T. Fukuhara, Y. Mano, K. Takeishi, T. Toshima, N. Harada, H. Uchiyama, T. Yoshizumi, Y. Soejima, K. Shirabe, Y. Matsuura, Y. Maehara

Research output: Contribution to journalArticle

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Abstract

IL28B genetic polymorphism is related to interferon-sensitivity in chronic hepatitis C, but the significance of grafts carrying different genotypes from recipients is still unclear in liver transplantation. A 51-year-old Japanese male carrying a minor genotype underwent dual liver transplantation for liver cirrhosis due to hepatitis C virus (HCV). The left lobe graft carried a major genotype, and the right a minor genotype. He achieved virological response during the course of pegylated-interferon and ribavirin therapy against recurrent hepatitis C for 2 years, but HCV relapsed immediately at the end of the therapy. Two years after antiviral therapy, liver biopsy was performed from each graft. The specimens showed A1F0 in the left lobe graft and A2F2 in the right. Moreover, quantitative polymerase chain reaction was performed using RNA extracted from each specimen to see there was no HCV RNA in the left lobe whereas there was in the right. This case provides clear evidence that IL28B genetic variants determine interferon sensitivity in recurrent hepatitis C following liver transplantation, which could result in new strategies for donor selection or for posttransplant antiviral therapy to HCV positive recipients. In this dual graft liver transplantation case, each graft with different IL28B genotype showed significantly different pathological findings and viral kinetics after interferon therapy for recurrent hepatitis C.

Original languageEnglish
Pages (from-to)1325-1329
Number of pages5
JournalAmerican Journal of Transplantation
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

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Hepatitis C
Liver Transplantation
Transplants
Hepacivirus
Interferons
Genotype
Antiviral Agents
RNA
Therapeutics
Donor Selection
Ribavirin
Genetic Polymorphisms
Chronic Hepatitis C
Liver Cirrhosis
Biopsy
Polymerase Chain Reaction
Liver

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation : Significant lessons from a dual graft case. / Motomura, T.; Taketomi, A.; Fukuhara, T.; Mano, Y.; Takeishi, K.; Toshima, T.; Harada, N.; Uchiyama, H.; Yoshizumi, T.; Soejima, Y.; Shirabe, K.; Matsuura, Y.; Maehara, Y.

In: American Journal of Transplantation, Vol. 11, No. 6, 01.06.2011, p. 1325-1329.

Research output: Contribution to journalArticle

Motomura, T. ; Taketomi, A. ; Fukuhara, T. ; Mano, Y. ; Takeishi, K. ; Toshima, T. ; Harada, N. ; Uchiyama, H. ; Yoshizumi, T. ; Soejima, Y. ; Shirabe, K. ; Matsuura, Y. ; Maehara, Y. / The impact of IL28B genetic variants on recurrent hepatitis C in liver transplantation : Significant lessons from a dual graft case. In: American Journal of Transplantation. 2011 ; Vol. 11, No. 6. pp. 1325-1329.
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