The impact of pegylated-interferon α-2b on partial and massive hepatectomy model in rats

Hiroki Mori, Mitsuo Shimada, Tohru Ikegami, Tohru Utsunomiya, Satoru Imura, Yuji Morine, Tetsuya Ikemoto, Jun Hanaoka, Shuichi Iwahashi, Yu Saito, Michihito Asanoma, Shinichiro Yamada, Hidenori Miyake

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: The impact of pegylated-interferon (PEG-IFN) α-2b on liver regeneration has not yet been elucidated. Methodology: Rats were divided into the following four groups: 70% hepatectomy (Hx); 70% Hx+PEG-IFN; 90% Hx and 90% Hx+PEG-IFN group (n=6 each). Rats were pretreated with subcutaneous of PEG-IFN αa-2b (1.5μg/kg) administration 24 hours before Hx. Samples were taken 24, 48 and 72 hours after Hx and the following parameters were investigated: blood analysis (AST, WBC, PLT); liver weight to body weight ratio (Lw/Bw ratio); survival and PCNA labeling index (LI). Results: In the 90% Hx model, there was no significant difference between the Hx+PEG-IFN group and the Hx alone group in blood analysis; AST after postoperative 24 hours (2511 vs. 2466IU/L), WBC (1200 vs. 1290) and PLT (107 vs. 111 × 10 4/mm3), in Lw/Bw ratio at postoperative 0, 24, 48, 72 hours, respectively (0.38, 0.60, 1.14, 1.69 vs. 0.37, 0.64, 1.12, 1.63), in postoperative survival (40% vs. 45%), and in PCNA LI at postoperative 0, 24, 48, 72 hours, respectively (10.4%, 16.8%, 14.6%, 12.8% vs. 10.0%, 17.1%, 15.6%, 13.7%). In the 70% Hx model, there was no significant difference between the Hx+PEG-IFN group and the Hx alone group for all parameters. Conclusions: Our data demonstrated that PEG-IFN α-2b did not affect liver regeneration and the early use of PEG-IFN α-2b would cause no problems after liver transplantation using partial grafts including living donor liver transplantation.

Original languageEnglish
Pages (from-to)2300-2304
Number of pages5
JournalHepato-gastroenterology
Volume59
Issue number119
DOIs
Publication statusPublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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