The Impact of Response to Cardiac Resynchronization Therapy on Ventricular Arrhythmic Events in CUBIC Registry

Kenji Ando, Takeshi Arita, Masahiko Goya, Masakiyo Nobuyoshi, Satoshi Shizuta, Takeshi Kimura, Satoki Fujii

Research output: Contribution to journalArticle


Background: It is well known that CRT is effective to reduce heart failure hospitalization and prolong survival. However, the impact of response to CRT on ventricular arrhythmias (VA) is not well established. Methods: We investigated 436 patients without history of VA, who could obtain pre and 6 month echo data, from CUBIC study which is a Japanese multicenter CRT registry (age 70+/-11years, NYHA class 2.9+/-0.6, female 32%, ischemic etiology29%, LVEF 28+/-10%, LVEDD 62+/-9mm, QRS duration 151+/-37ms, CRT-D 54%) and divided into two groups, 262 (60%) CRT responders (R-group) and 174 (40%) CRT non-responders (NR group). Results: After mean follow up 26+/14 months, survival rate, event free survival rate from heart failure hospitalization and event free survival rate from combined death and heart failure hospitalization were all significantly higher in R group compared to NR group (95% vs. 78% at 2-year, Log-rank p<0.0001, 83% vs. 59% at 2-year, Log-rank p<0.0001, 81% vs. 53% at 2-year, Log-rank p<0.0001, respectively). Furthermore, event free survival rate from combined VT, VF, ICD therapy for VT or VF, and sudden cardiac death was also significantly higher in R group (90% vs. 81% at 2-year, Log-rank p=0.008). Conclusion: Response to CRT seems not only to reduce heart failure events or prolong survival, but also to prevent VA.

Original languageEnglish
Number of pages1
Journaljournal of arrhythmia
Issue number4
Publication statusPublished - Jan 1 2011


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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