@article{2fb64c75310d498db0cb4a11d2d3fe1b,
title = "The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi-institutional retrospective analysis in Japan",
abstract = "Background: Salivary duct carcinoma (SDC) is a high-grade salivary malignancy that frequently occurs as the carcinomatous component of carcinoma ex pleomorphic adenoma. We herein examined the clinical factors affecting outcomes in a large cohort of SDC. Methods: We selected 304 SDC cases and investigated clinical characteristics and the factors affecting outcomes. Results: The median age of the cases examined was 68 years, the most common primary site was the parotid gland (238 cases), and there was a male predominance (M/F = 5:1). Outcomes were significantly worse when the primary tumor site was the minor salivary glands (SG) than when it was the major SG. Outcomes were also significantly worse in pN(+) cases (161 cases) than in pN0 cases, particularly those with a metastatic lymph node number ≥11. The cumulative incidence of relapse and distant metastases was significantly higher in stage IV cases than in stage 0–III cases. Conclusions: The absolute number of lymph node metastases, higher stages, and the minor SG as the primary tumor site were identified as factors affecting the outcome of SDC.",
author = "Kimihide Kusafuka and Yoko Sato and Eiji Nakatani and Satoshi Baba and Matsuyoshi Maeda and Koji Yamanegi and Kaori Ueda and Hiroshi Inagaki and Yoshiro Otsuki and Naoto Kuroda and Kensuke Suzuki and Hiroshi Iwai and Yoshiaki Imamura and Junya Itakura and Shoji Yamanaka and Hideaki Takahashi and Ichiro Ito and Takumi Akashi and Tsutomu Daa and Mei Hamada and Masanori Yasuda and Ryo Kawata and Hidetaka Yamamoto and Yuri Tachibana and Junya Fukuoka and Aya Muramatsu and Kazumori Arai and Makoto Suzuki",
note = "Funding Information: Shizuoka Prefectural Hospital Organization; Ministry of Education, Culture, Sports, Science and Technology of Japan, Grant/Award Number: 15K08351 Funding information Funding Information: The authors thank Mr. Naofumi Ishikawa, Ms. Yoko Yamazaki, Mr. Tomohiro Iwasaki, Ms. Chinatsu Tsuchiya, Ms. Aki Kubota, Mr. Kensuke Shimazaki, Mr. Kazuki Hirata, Mr. Koji Takahashi, Ms. Nobuyo Tsujino, and Mr. Yosuke Saguchi, the co-medical staff of Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan, for providing technical assistance. We are grateful to Ms. Mamiko Uemura, secretariat, Department of Pathology, Shizuoka General Hospital, Shizuoka, Japan. This work was supported in part by a Grant-in-Aid for Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (15K08351 to Hiroshi Inagaki) and a Grant-in-Aid for Medical Research Support Project of Shizuoka Prefectural Hospital Organization in 2019 of Japan (to Kimihide Kusafuka). Publisher Copyright: {\textcopyright} 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.",
year = "2022",
month = jun,
doi = "10.1002/hed.27034",
language = "English",
volume = "44",
pages = "1430--1441",
journal = "Head and Neck Surgery",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "6",
}