The in vitro antibiotic release from anti-washout apatite cement using chitosan

Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seikou Tatehara, Masaru Nagayama, Kunio Ishikawa, Kazuomi Suzuki

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30 Citations (Scopus)

Abstract

The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10%. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-AC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10% flomoxef sodium (0% vs. 10%) was not significant (p > 0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24h, when the aw-AC(chi) contained flomoxef sodium at 8% or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, we conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations.

Original languageEnglish
Pages (from-to)973-978
Number of pages6
JournalJournal of Materials Science: Materials in Medicine
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 1 2002
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Takechi, M., Miyamoto, Y., Momota, Y., Yuasa, T., Tatehara, S., Nagayama, M., ... Suzuki, K. (2002). The in vitro antibiotic release from anti-washout apatite cement using chitosan. Journal of Materials Science: Materials in Medicine, 13(10), 973-978. https://doi.org/10.1023/A:1019816830793