The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer

Shinichiro Shimamatsu, Mitsuhiro Takenoyama, Mototsugu Shimokawa, Kazuki Takada, Makoto Edagawa, Ryo Toyozawa, Kaname Nosaki, Taro Oba, Tetsuzo Tagawa, Masafumi Yamaguchi, Kenichi Taguchi, Takashi Seto

Research output: Contribution to journalArticle

Abstract

Background: We investigated the utility of the clinical T factor of the 8th edition of the TNM classification, which newly defines the consolidation size of the tumor, as a valuable predictor of pathologic lymph node metastasis (pN+) and the prognosis. Methods: We retrospectively reviewed 825 patients with surgically resected cN0 M0 non-small cell lung cancer of any T stage, focusing on the tumor's total size (7th edition) and consolidation size (8th edition) and examined pN+ and the prognosis. Results: No pN+ cases in the 7th or 8th edition groups had a tumor size of less than 1 cm, and in those sized 1 to 3 cm, the frequency of pN+ in the 7th and 8th edition groups was 10.3% and 13.4%, respectively. The frequency of pN+ in tumors without ground glass opacity (GGO−) was 5.5-times higher than that of tumors with GGO (GGO+). The frequency of pN+ in the GGO+ 8th edition group was twice that in the GGO+ 7th edition group. The frequency of pN+ in the GGO− 7th edition group was 4-times higher than that of the GGO+ 7th edition group. A multivariate analysis revealed that total size exceeding 2 cm, consolidation size exceeding 2 cm, and GGO− were significant predictors of a pN+ status, indicating that a consolidation size of more than 2 cm was a stronger predictor than a total size of more than 2 cm. Conclusions: A consolidation size of more than 2 cm and GGO− were predictors of pN+, and the clinical T factor of the 8th Edition was a stronger predictor of the pN+ status than that of the 7th edition.

Original languageEnglish
Pages (from-to)1080-1086
Number of pages7
JournalAnnals of Thoracic Surgery
Volume108
Issue number4
DOIs
Publication statusPublished - Oct 2019

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer'. Together they form a unique fingerprint.

  • Cite this

    Shimamatsu, S., Takenoyama, M., Shimokawa, M., Takada, K., Edagawa, M., Toyozawa, R., Nosaki, K., Oba, T., Tagawa, T., Yamaguchi, M., Taguchi, K., & Seto, T. (2019). The Influence of Clinical T Factor on Predicting Pathologic N Factor in Resected Lung Cancer. Annals of Thoracic Surgery, 108(4), 1080-1086. https://doi.org/10.1016/j.athoracsur.2019.04.026