The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalPhytomedicine
Volume22
Issue number1
DOIs
Publication statusPublished - Mar 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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