The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

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Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.

Original languageEnglish
Pages (from-to)49-51
Number of pages3
JournalPhytomedicine
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Garcinia mangostana
Aldehyde Reductase
Methylene Chloride
Inhibitory Concentration 50
Plant Bark
Xanthones
Indonesia
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine
  • Medicine(all)

Cite this

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn. / Fatmawati, Sri; Ersam, Taslim; Shimizu, Kuniyoshi.

In: Phytomedicine, Vol. 22, No. 1, 01.01.2015, p. 49-51.

Research output: Contribution to journalArticle

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