The inhibitory components from Artocarpus incisus on melanin biosynthesis

Kuniyoshi Shimizu, Ryuichiro Kondo, Kokki Sakai, Seon Ho Lee, Hiroaki Sato

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The inhibitory effects of methanol extracts of heartwood of 23 Papua New Guinean wood species on tyrosinase activity were examined. The extract of Artocarpus incisus showed the strongest tyrosinase inhibitory activity which was equivalent to kojic acid. The extract apparently inhibited melanin biosynthesis of both cultured B16 melanoma cells without any cytotoxicity and in the back of a brown guinea pig without skin irritation. Thus, the potentiality of the extracts of heartwood of R. incisus both as material of a useful skin whitening agent and as a remedy for disturbances in pigmentation is evident. Tyrosinase inhibitory activity-guided fractionation led to the isolation of seven active compounds including a new compound which has been characterized as 6-(3'-methyl-1'-butenyl)-5,7,2',4'-tetrahydroxyflavone, named isoartocarpesin. Other active compounds were (+)-dihydromorin, chlorophorin, (+)-norartocarpanone, 4-prenyloxyresveratrol, artocarbene, and artocarpesin. These compounds are probably responsible for the melanin biosynthesis inhibitory effects.

Original languageEnglish
Pages (from-to)408-412
Number of pages5
JournalPlanta medica
Volume64
Issue number5
DOIs
Publication statusPublished - Jul 13 1998

Fingerprint

Artocarpus
Monophenol Monooxygenase
Biosynthesis
Melanins
Skin Lightening Preparations
Skin
Bleaching Agents
Experimental Melanomas
Pigmentation
Cytotoxicity
Fractionation
Methanol
Wood
Guinea Pigs

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

The inhibitory components from Artocarpus incisus on melanin biosynthesis. / Shimizu, Kuniyoshi; Kondo, Ryuichiro; Sakai, Kokki; Lee, Seon Ho; Sato, Hiroaki.

In: Planta medica, Vol. 64, No. 5, 13.07.1998, p. 408-412.

Research output: Contribution to journalArticle

Shimizu, Kuniyoshi ; Kondo, Ryuichiro ; Sakai, Kokki ; Lee, Seon Ho ; Sato, Hiroaki. / The inhibitory components from Artocarpus incisus on melanin biosynthesis. In: Planta medica. 1998 ; Vol. 64, No. 5. pp. 408-412.
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