The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum

Sri Fatmawati, Kenji Kurashiki, Sayaka Takeno, Yong Ung Kim, Kuniyoshi Shimizu, Masao Sato, Katsumi Imaizumi, Kaori Takahashi, Shinji Kamiya, Shuhei Kaneko, Ryuichiro Kondo

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Abstract

The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalPhytotherapy Research
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Fatmawati, S., Kurashiki, K., Takeno, S., Kim, Y. U., Shimizu, K., Sato, M., Imaizumi, K., Takahashi, K., Kamiya, S., Kaneko, S., & Kondo, R. (2009). The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum. Phytotherapy Research, 23(1), 28-32. https://doi.org/10.1002/ptr.2425