The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation

Akira Yano, Sayaka Kikuchi, Yoshihisa Yamashita, Yuichi Sakamoto, Yuko Nakagawa, Yasuo Yoshida

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mushrooms contain large quantities of α-glucans. Shiitake (Lentinula edodes), Japan's most popular edible mushroom, has been reported to contain about 6% (weight/dried weight) of α-(1,3)-glucan. This glucan is one of the major components of oral biofilm formed by the cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus. We found that extracts from shiitake and other edible mushrooms could reduce preformed biofilms of S. mutans and S. sobrinus in the presence of dextranase. We also investigated the α-glucanase activities of shiitake mushroom extracts and their effects on biofilm formation. The extracts possessed α-glucanase activity and degraded water-insoluble glucans from mutans streptococci. The extracts strongly inhibited the sucrose-dependent formation of biofilms by S. mutans and S. sobrinus in the presence of dextranase. Our results suggest that some components of mushrooms, including α-glucanases, might inhibit the sucrose-induced formation of oral biofilms.

Original languageEnglish
Pages (from-to)615-623
Number of pages9
JournalApplied Microbiology and Biotechnology
Volume86
Issue number2
DOIs
Publication statusPublished - Mar 1 2010

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Agaricales
Biofilms
Streptococcus mutans
Glucans
Streptococcus sobrinus
Sucrose
Dextranase
Shiitake Mushrooms
Weights and Measures
Japan
Bacteria
Water

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation. / Yano, Akira; Kikuchi, Sayaka; Yamashita, Yoshihisa; Sakamoto, Yuichi; Nakagawa, Yuko; Yoshida, Yasuo.

In: Applied Microbiology and Biotechnology, Vol. 86, No. 2, 01.03.2010, p. 615-623.

Research output: Contribution to journalArticle

Yano, Akira ; Kikuchi, Sayaka ; Yamashita, Yoshihisa ; Sakamoto, Yuichi ; Nakagawa, Yuko ; Yoshida, Yasuo. / The inhibitory effects of mushroom extracts on sucrose-dependent oral biofilm formation. In: Applied Microbiology and Biotechnology. 2010 ; Vol. 86, No. 2. pp. 615-623.
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