The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells

Enos Tangke Arung, Shoko Furuta, Kazuhiro Sugamoto, Kuniyoshi Shimizu, Hiroya Ishikawa, Yoh Ichi Matsushita, Ryuichiro Kondo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.

Original languageEnglish
Pages (from-to)1007-1010
Number of pages4
JournalNatural product communications
Volume7
Issue number8
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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