The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells

Enos Tangke Arung, Shoko Furuta, Kazuhiro Sugamoto, Kuniyoshi Shimizu, Hiroya Ishikawa, Yoh Ichi Matsushita, Ryuichiro Kondo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.

Original languageEnglish
Pages (from-to)1007-1010
Number of pages4
JournalNatural Product Communications
Volume7
Issue number8
Publication statusPublished - Aug 28 2012

Fingerprint

Angelica
Chalcones
chalcones
Experimental Melanomas
Melanins
melanin
melanoma
biosynthesis
Bleaching Agents
Monophenol Monooxygenase
cells
cytotoxicity
Antioxidants
antioxidants
stems
assays
Angelica keiskei
xanthoangelol

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

Arung, E. T., Furuta, S., Sugamoto, K., Shimizu, K., Ishikawa, H., Matsushita, Y. I., & Kondo, R. (2012). The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. Natural Product Communications, 7(8), 1007-1010.

The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. / Arung, Enos Tangke; Furuta, Shoko; Sugamoto, Kazuhiro; Shimizu, Kuniyoshi; Ishikawa, Hiroya; Matsushita, Yoh Ichi; Kondo, Ryuichiro.

In: Natural Product Communications, Vol. 7, No. 8, 28.08.2012, p. 1007-1010.

Research output: Contribution to journalArticle

Arung, ET, Furuta, S, Sugamoto, K, Shimizu, K, Ishikawa, H, Matsushita, YI & Kondo, R 2012, 'The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells', Natural Product Communications, vol. 7, no. 8, pp. 1007-1010.
Arung, Enos Tangke ; Furuta, Shoko ; Sugamoto, Kazuhiro ; Shimizu, Kuniyoshi ; Ishikawa, Hiroya ; Matsushita, Yoh Ichi ; Kondo, Ryuichiro. / The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. In: Natural Product Communications. 2012 ; Vol. 7, No. 8. pp. 1007-1010.
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