The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population

Yuichiro Nishida, Tsuyoshi Hachiya, Megumi Hara, Chisato Shimanoe, Keitaro Tanaka, Yoichi Sutoh, Atsushi Shimizu, Asahi Hishida, Mineko Tsukamoto, Yuka Kadomatsu, Isao Oze, Yuriko N. Koyanagi, Nagato Kuriyama, Teruhide Koyama, Rie Ibusuki, Toshiro Takezaki, Hiroaki Ikezaki, Norihiro Furusyo, Naoyuki Takashima, Aya KadotaHirokazu Uemura, Sakurako Katsuura-Kamano, Sadao Suzuki, Hiroko Nakagawa-Senda, Kiyonori Kuriki, Haruo Mikami, Yohko Nakamura, Yukihide Momozawa, Michiaki Kubo, Masahiro Nakatochi, Mariko Naito, Kenji Wakai

Research output: Contribution to journalArticle

Abstract

Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDLC- related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-Crelated SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β= 0.032) or high PA (β= 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalJournal of Lipid Research
Volume61
Issue number1
DOIs
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Cell Biology

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    Nishida, Y., Hachiya, T., Hara, M., Shimanoe, C., Tanaka, K., Sutoh, Y., Shimizu, A., Hishida, A., Tsukamoto, M., Kadomatsu, Y., Oze, I., Koyanagi, Y. N., Kuriyama, N., Koyama, T., Ibusuki, R., Takezaki, T., Ikezaki, H., Furusyo, N., Takashima, N., ... Wakai, K. (2020). The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population. Journal of Lipid Research, 61(1), 86-94. https://doi.org/10.1194/jlr.P091546