The life cycle of the GABAA receptor and its regulating molecules

Takashi Kanematsu, Miho Terunuma, Hidefumi Goto, Akiko Kuratani, Masato Hirata

Research output: Contribution to journalReview article

Abstract

γ-Aminobutyric acidA (GABAA) receptors mediate most of the fast inhibitory neurotransmission in the central nervous system. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. This review highlights recent findings on the regulation of GABAA-receptor expression and function, focusing on the mechanisms of sorting, targeting, synaptic clustering, and endocytic events of GABAA receptors, all which are regulated by their associated proteins. Now these topics are an area of active interest in studies on inhibitory neurotransmission.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalFolia Pharmacologica Japonica
Volume123
Issue number2
DOIs
Publication statusPublished - Feb 23 2004

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this