TY - JOUR
T1 - The lipocalin 24p3, which is an essential molecule in IL-3 withdrawal-induced apoptosis, is not involved in the G-CSF withdrawal-induced apoptosis
AU - Kamezaki, Kenjirou
AU - Shimoda, Kazuya
AU - Numata, Akihiko
AU - Aoki, Kenichi
AU - Kato, Kouji
AU - Takase, Ken
AU - Nakajima, Hideaki
AU - Ihara, Kenji
AU - Haro, Takashi
AU - Ishikawa, Fumihiko
AU - Imamura, Rie
AU - Miyamoto, Toshihiro
AU - Nagafuji, Koji
AU - Gondo, Hisashi
AU - Hara, Toshiro
AU - Harada, Mine
PY - 2003/12
Y1 - 2003/12
N2 - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
AB - Many hematopoietic cells undergo apoptosis when deprived of specific cytokines. Lipocalin 24p3, reported to be induced in hematopoietic cells by interleukin 3 (IL-3) depletion, induces hematopoietic cell apoptosis despite the presence of IL-3. As granulocyte colony stimulating factor (G-CSF) depletion also induces the apoptosis of G-CSF-dependent cell line cells, we examined the effect of 24p3 on the apoptotic function induced by G-CSF depletion. 24p3 was induced by the depletion of IL-3, but not G-CSF, in cytokine-dependent cell lines. Although 24p3 suppressed growth induced by IL-3, it did not influence G-CSF-dependent cell growth. These observations show that 24p3 is not involved in the G-CSF withdrawal-induced apoptosis, although it is essential in IL-3 withdrawal-induced apoptosis.
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U2 - 10.1046/j.0902-4441.2003.00160.x
DO - 10.1046/j.0902-4441.2003.00160.x
M3 - Article
C2 - 14703690
AN - SCOPUS:10744233531
VL - 71
SP - 412
EP - 417
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 6
ER -