The long-term association between physical activity and risk of dementia in the community

the Hisayama Study

Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We investigated the long-term influence of physical activity on the risk of dementia in an elderly Japanese population. A total of 803 community-dwelling elderly Japanese individuals without dementia aged ≥65 years were followed prospectively for 17 years. Physically active status was defined as engaging in exercise at least one or more times per week during leisure time, and participants were divided into an active group and an inactive group by the presence or absence of such physical activity. The risk estimates of physical activity on the development of all-cause dementia and its subtypes were computed using a Cox proportional hazards model. During the follow-up, 291 participants developed all-cause dementia. Of these, 165 had Alzheimer’s disease (AD), 93 had vascular dementia (VaD), and 47 had other dementia. Compared with the inactive group, the active group showed significantly lower crude incidence of AD (21.8 vs. 14.2 per 1000 person-years, p = 0.01), but no significant differences were observed for all-cause dementia (35.6 vs. 30.5, p = 0.17), VaD (11.3 vs. 9.8, p = 049), and other dementia (4.6 vs. 7.1, p = 0.15). After adjusting for potential confounders, the relationship between physical activity and risk of AD remained significant (adjusted hazard ratio 0.59, 95 % confidence interval 0.41–0.84, p = 0.003). Our findings suggest that physical activity reduces the long-term risk of dementia, especially AD, in the general Japanese population.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalEuropean Journal of Epidemiology
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Dementia
Exercise
Alzheimer Disease
Vascular Dementia
Independent Living
Leisure Activities
Proportional Hazards Models
Population
Confidence Intervals
Incidence

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

The long-term association between physical activity and risk of dementia in the community : the Hisayama Study. / Kishimoto, Hiro; Ohara, Tomoyuki; Hata, Jun; Ninomiya, Toshiharu; Yoshida, Daigo; Mukai, Naoko; Nagata, Masaharu; Ikeda, Fumie; Fukuhara, Masayo; Kumagai, Shuzo; Kanba, Shigenobu; Kitazono, Takanari; Kiyohara, Yutaka.

In: European Journal of Epidemiology, Vol. 31, No. 3, 01.03.2016, p. 267-274.

Research output: Contribution to journalArticle

@article{4e1dfeed92bb4c039de273a237eb489d,
title = "The long-term association between physical activity and risk of dementia in the community: the Hisayama Study",
abstract = "We investigated the long-term influence of physical activity on the risk of dementia in an elderly Japanese population. A total of 803 community-dwelling elderly Japanese individuals without dementia aged ≥65 years were followed prospectively for 17 years. Physically active status was defined as engaging in exercise at least one or more times per week during leisure time, and participants were divided into an active group and an inactive group by the presence or absence of such physical activity. The risk estimates of physical activity on the development of all-cause dementia and its subtypes were computed using a Cox proportional hazards model. During the follow-up, 291 participants developed all-cause dementia. Of these, 165 had Alzheimer’s disease (AD), 93 had vascular dementia (VaD), and 47 had other dementia. Compared with the inactive group, the active group showed significantly lower crude incidence of AD (21.8 vs. 14.2 per 1000 person-years, p = 0.01), but no significant differences were observed for all-cause dementia (35.6 vs. 30.5, p = 0.17), VaD (11.3 vs. 9.8, p = 049), and other dementia (4.6 vs. 7.1, p = 0.15). After adjusting for potential confounders, the relationship between physical activity and risk of AD remained significant (adjusted hazard ratio 0.59, 95 {\%} confidence interval 0.41–0.84, p = 0.003). Our findings suggest that physical activity reduces the long-term risk of dementia, especially AD, in the general Japanese population.",
author = "Hiro Kishimoto and Tomoyuki Ohara and Jun Hata and Toshiharu Ninomiya and Daigo Yoshida and Naoko Mukai and Masaharu Nagata and Fumie Ikeda and Masayo Fukuhara and Shuzo Kumagai and Shigenobu Kanba and Takanari Kitazono and Yutaka Kiyohara",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/s10654-016-0125-y",
language = "English",
volume = "31",
pages = "267--274",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer Netherlands",
number = "3",

}

TY - JOUR

T1 - The long-term association between physical activity and risk of dementia in the community

T2 - the Hisayama Study

AU - Kishimoto, Hiro

AU - Ohara, Tomoyuki

AU - Hata, Jun

AU - Ninomiya, Toshiharu

AU - Yoshida, Daigo

AU - Mukai, Naoko

AU - Nagata, Masaharu

AU - Ikeda, Fumie

AU - Fukuhara, Masayo

AU - Kumagai, Shuzo

AU - Kanba, Shigenobu

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

PY - 2016/3/1

Y1 - 2016/3/1

N2 - We investigated the long-term influence of physical activity on the risk of dementia in an elderly Japanese population. A total of 803 community-dwelling elderly Japanese individuals without dementia aged ≥65 years were followed prospectively for 17 years. Physically active status was defined as engaging in exercise at least one or more times per week during leisure time, and participants were divided into an active group and an inactive group by the presence or absence of such physical activity. The risk estimates of physical activity on the development of all-cause dementia and its subtypes were computed using a Cox proportional hazards model. During the follow-up, 291 participants developed all-cause dementia. Of these, 165 had Alzheimer’s disease (AD), 93 had vascular dementia (VaD), and 47 had other dementia. Compared with the inactive group, the active group showed significantly lower crude incidence of AD (21.8 vs. 14.2 per 1000 person-years, p = 0.01), but no significant differences were observed for all-cause dementia (35.6 vs. 30.5, p = 0.17), VaD (11.3 vs. 9.8, p = 049), and other dementia (4.6 vs. 7.1, p = 0.15). After adjusting for potential confounders, the relationship between physical activity and risk of AD remained significant (adjusted hazard ratio 0.59, 95 % confidence interval 0.41–0.84, p = 0.003). Our findings suggest that physical activity reduces the long-term risk of dementia, especially AD, in the general Japanese population.

AB - We investigated the long-term influence of physical activity on the risk of dementia in an elderly Japanese population. A total of 803 community-dwelling elderly Japanese individuals without dementia aged ≥65 years were followed prospectively for 17 years. Physically active status was defined as engaging in exercise at least one or more times per week during leisure time, and participants were divided into an active group and an inactive group by the presence or absence of such physical activity. The risk estimates of physical activity on the development of all-cause dementia and its subtypes were computed using a Cox proportional hazards model. During the follow-up, 291 participants developed all-cause dementia. Of these, 165 had Alzheimer’s disease (AD), 93 had vascular dementia (VaD), and 47 had other dementia. Compared with the inactive group, the active group showed significantly lower crude incidence of AD (21.8 vs. 14.2 per 1000 person-years, p = 0.01), but no significant differences were observed for all-cause dementia (35.6 vs. 30.5, p = 0.17), VaD (11.3 vs. 9.8, p = 049), and other dementia (4.6 vs. 7.1, p = 0.15). After adjusting for potential confounders, the relationship between physical activity and risk of AD remained significant (adjusted hazard ratio 0.59, 95 % confidence interval 0.41–0.84, p = 0.003). Our findings suggest that physical activity reduces the long-term risk of dementia, especially AD, in the general Japanese population.

UR - http://www.scopus.com/inward/record.url?scp=84957601063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957601063&partnerID=8YFLogxK

U2 - 10.1007/s10654-016-0125-y

DO - 10.1007/s10654-016-0125-y

M3 - Article

VL - 31

SP - 267

EP - 274

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 3

ER -