The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias

Noriaki Usui, Hiroomi Okuyama, Yutaka Kanamori, Kouji Nagata, Masahiro Hayakawa, Noboru Inamura, Shigehiro Takahashi, Tomoaki Taguchi

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Abstract

Background/Purpose The purpose of this study was to clarify the relationship between the lung to thorax transverse area ratio (L/T ratio) and the observed to expected lung area to head circumference ratio (O/E LHR), based on the results of a nationwide Japanese survey conducted in 2011, and to evaluate the compatibility of these prognostic predictors of fetal CDH. Methods Two hundred and forty-two prenatally diagnosed isolated CDH patients born between 2006 and 2010 were included in the present analysis. A regression analysis was conducted to investigate the relationship between the L/T ratio and the O/E LHR based on 191 simultaneous measurements of these parameters in 120 patients. Results The linear regression equation between the L/T ratio and the O/E LHR was: L/T ratio = 0.0233 + (0.00222 × O/E LHR), (R = 0.847, p < 0.0001). According to this equation, 25% of the O/E LHR, the cut-off value used in the fetal intervention for CDH, was equivalent to an L/T ratio of 0.08, a commonly accepted cut-off value for identifying the most severe cases of fetal CDH. Conclusions As there is a positive correlation between the L/T ratio and the O/E LHR, these two parameters proved to be used interchangeably according to the linear regression equation.

Original languageEnglish
Pages (from-to)1191-1196
Number of pages6
JournalJournal of Pediatric Surgery
Volume49
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

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Linear Models
Fetus
Thorax
Head
Lung
Regression Analysis
Congenital Diaphragmatic Hernias
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Medicine(all)

Cite this

The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias. / Usui, Noriaki; Okuyama, Hiroomi; Kanamori, Yutaka; Nagata, Kouji; Hayakawa, Masahiro; Inamura, Noboru; Takahashi, Shigehiro; Taguchi, Tomoaki.

In: Journal of Pediatric Surgery, Vol. 49, No. 8, 01.01.2014, p. 1191-1196.

Research output: Contribution to journalArticle

Usui, Noriaki ; Okuyama, Hiroomi ; Kanamori, Yutaka ; Nagata, Kouji ; Hayakawa, Masahiro ; Inamura, Noboru ; Takahashi, Shigehiro ; Taguchi, Tomoaki. / The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias. In: Journal of Pediatric Surgery. 2014 ; Vol. 49, No. 8. pp. 1191-1196.
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abstract = "Background/Purpose The purpose of this study was to clarify the relationship between the lung to thorax transverse area ratio (L/T ratio) and the observed to expected lung area to head circumference ratio (O/E LHR), based on the results of a nationwide Japanese survey conducted in 2011, and to evaluate the compatibility of these prognostic predictors of fetal CDH. Methods Two hundred and forty-two prenatally diagnosed isolated CDH patients born between 2006 and 2010 were included in the present analysis. A regression analysis was conducted to investigate the relationship between the L/T ratio and the O/E LHR based on 191 simultaneous measurements of these parameters in 120 patients. Results The linear regression equation between the L/T ratio and the O/E LHR was: L/T ratio = 0.0233 + (0.00222 × O/E LHR), (R = 0.847, p < 0.0001). According to this equation, 25{\%} of the O/E LHR, the cut-off value used in the fetal intervention for CDH, was equivalent to an L/T ratio of 0.08, a commonly accepted cut-off value for identifying the most severe cases of fetal CDH. Conclusions As there is a positive correlation between the L/T ratio and the O/E LHR, these two parameters proved to be used interchangeably according to the linear regression equation.",
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AU - Kanamori, Yutaka

AU - Nagata, Kouji

AU - Hayakawa, Masahiro

AU - Inamura, Noboru

AU - Takahashi, Shigehiro

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