TY - JOUR
T1 - The measles virus hemagglutinin downregulates the cellular receptor SLAM (CD150)
AU - Tanaka, K.
AU - Minagawa, H.
AU - Xie, M. F.
AU - Yanagi, Y.
PY - 2002
Y1 - 2002
N2 - Signaling lymphocyte activation molecule (SLAM), a cellular receptor for measles virus, was downregulated from the surface of cells infected with either the Edmonston or wild-type KA strain of measles virus. Transfection of the expression plasmid encoding the Edmonston or KA hemagglutinin, but not the fusion protein, induced downregulation of SLAM in not only cells expressing the envelope protein on the surface, but those not expressing it. After cocultivation with cells expressing the hemagglutinin, SLAM-expressing cells also exhibited downregulation of SLAM. Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it.
AB - Signaling lymphocyte activation molecule (SLAM), a cellular receptor for measles virus, was downregulated from the surface of cells infected with either the Edmonston or wild-type KA strain of measles virus. Transfection of the expression plasmid encoding the Edmonston or KA hemagglutinin, but not the fusion protein, induced downregulation of SLAM in not only cells expressing the envelope protein on the surface, but those not expressing it. After cocultivation with cells expressing the hemagglutinin, SLAM-expressing cells also exhibited downregulation of SLAM. Thus, the measles virus hemagglutinin can induce downregulation of SLAM in cells either expressing or coming in contact with it.
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U2 - 10.1007/s705-002-8312-0
DO - 10.1007/s705-002-8312-0
M3 - Article
C2 - 11855632
AN - SCOPUS:0036007494
VL - 147
SP - 195
EP - 203
JO - Archives of Virology
JF - Archives of Virology
SN - 0304-8608
IS - 1
ER -
