The mechanism and control of neuropathic pain

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neuropathic pain is a debilitating pain that occurs after nerve injury and is generally resistant to currently available treatments including morphine. Such pain involves aberrant excitability in dorsal horn neurons after nerve injury. Emerging evidence indicate that the enhanced activity of dorsal horn neurons requires a communication with microglia. Results of our laboratory have shown that activating P2X4R upregulated in spinal microglia after nerve injury contributes to neuropathic pain through a release of BDNF from microglia, which is a crucial factor to signal to dorsal horn neurons to cause neuronal hyp erexcitability. Activated spinal microglia also express P2Y 12R, and P2Y12R-KO mice display impaired neuropathic pain. The mechanisms of microglia activation are unknown, but our recent study shows that interferon-γ (IFN-γ) can be an important factor that causes spinal microglia activation after nerve injury. IFN-γ upregulates P2X 4R in microglia and causes P2X4R-dependent allodynia. These findings suggest that purinoceptors in spinal microglia is crucial for pathological intractable pain.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalClinical Neurology
Volume49
Issue number11
DOIs
Publication statusPublished - Dec 1 2009

Fingerprint

Microglia
Neuralgia
Posterior Horn Cells
Wounds and Injuries
Interferons
Purinergic Receptors
Pain
Intractable Pain
Hyperalgesia
Brain-Derived Neurotrophic Factor
Morphine
Up-Regulation
Communication

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

The mechanism and control of neuropathic pain. / Inoue, Kazuhide.

In: Clinical Neurology, Vol. 49, No. 11, 01.12.2009, p. 779-782.

Research output: Contribution to journalArticle

@article{51c59187df1e49b091429d2e7a387bb8,
title = "The mechanism and control of neuropathic pain",
abstract = "Neuropathic pain is a debilitating pain that occurs after nerve injury and is generally resistant to currently available treatments including morphine. Such pain involves aberrant excitability in dorsal horn neurons after nerve injury. Emerging evidence indicate that the enhanced activity of dorsal horn neurons requires a communication with microglia. Results of our laboratory have shown that activating P2X4R upregulated in spinal microglia after nerve injury contributes to neuropathic pain through a release of BDNF from microglia, which is a crucial factor to signal to dorsal horn neurons to cause neuronal hyp erexcitability. Activated spinal microglia also express P2Y 12R, and P2Y12R-KO mice display impaired neuropathic pain. The mechanisms of microglia activation are unknown, but our recent study shows that interferon-γ (IFN-γ) can be an important factor that causes spinal microglia activation after nerve injury. IFN-γ upregulates P2X 4R in microglia and causes P2X4R-dependent allodynia. These findings suggest that purinoceptors in spinal microglia is crucial for pathological intractable pain.",
author = "Kazuhide Inoue",
year = "2009",
month = "12",
day = "1",
doi = "10.5692/clinicalneurol.49.779",
language = "English",
volume = "49",
pages = "779--782",
journal = "Clinical Neurology",
issn = "0009-918X",
publisher = "Societas Neurologica Japonica",
number = "11",

}

TY - JOUR

T1 - The mechanism and control of neuropathic pain

AU - Inoue, Kazuhide

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Neuropathic pain is a debilitating pain that occurs after nerve injury and is generally resistant to currently available treatments including morphine. Such pain involves aberrant excitability in dorsal horn neurons after nerve injury. Emerging evidence indicate that the enhanced activity of dorsal horn neurons requires a communication with microglia. Results of our laboratory have shown that activating P2X4R upregulated in spinal microglia after nerve injury contributes to neuropathic pain through a release of BDNF from microglia, which is a crucial factor to signal to dorsal horn neurons to cause neuronal hyp erexcitability. Activated spinal microglia also express P2Y 12R, and P2Y12R-KO mice display impaired neuropathic pain. The mechanisms of microglia activation are unknown, but our recent study shows that interferon-γ (IFN-γ) can be an important factor that causes spinal microglia activation after nerve injury. IFN-γ upregulates P2X 4R in microglia and causes P2X4R-dependent allodynia. These findings suggest that purinoceptors in spinal microglia is crucial for pathological intractable pain.

AB - Neuropathic pain is a debilitating pain that occurs after nerve injury and is generally resistant to currently available treatments including morphine. Such pain involves aberrant excitability in dorsal horn neurons after nerve injury. Emerging evidence indicate that the enhanced activity of dorsal horn neurons requires a communication with microglia. Results of our laboratory have shown that activating P2X4R upregulated in spinal microglia after nerve injury contributes to neuropathic pain through a release of BDNF from microglia, which is a crucial factor to signal to dorsal horn neurons to cause neuronal hyp erexcitability. Activated spinal microglia also express P2Y 12R, and P2Y12R-KO mice display impaired neuropathic pain. The mechanisms of microglia activation are unknown, but our recent study shows that interferon-γ (IFN-γ) can be an important factor that causes spinal microglia activation after nerve injury. IFN-γ upregulates P2X 4R in microglia and causes P2X4R-dependent allodynia. These findings suggest that purinoceptors in spinal microglia is crucial for pathological intractable pain.

UR - http://www.scopus.com/inward/record.url?scp=77956197206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956197206&partnerID=8YFLogxK

U2 - 10.5692/clinicalneurol.49.779

DO - 10.5692/clinicalneurol.49.779

M3 - Article

C2 - 20030208

AN - SCOPUS:77956197206

VL - 49

SP - 779

EP - 782

JO - Clinical Neurology

JF - Clinical Neurology

SN - 0009-918X

IS - 11

ER -