We recently proposed the novel gene-regulation polymer responding to cAMP-dependent protein kinase (PKA). However this polymer alone only had poor ability for the gene delivery into living cells. Thus it is difficult to evaluate the function of this polymer in living cells. On the other hand, it has been reported Arg-Gly-Asp (RGD) peptides modified polymer was efficiently deliveried genes into cells. In the present study, we modified the signal responsive polymer to RGD peptide for the introduction of polymer-DNA complex into living cells.
|Number of pages||1|
|Publication status||Published - Oct 19 2006|
|Event||55th SPSJ Annual Meeting - Nagoya, Japan|
Duration: May 24 2006 → May 26 2006
|Other||55th SPSJ Annual Meeting|
|Period||5/24/06 → 5/26/06|
All Science Journal Classification (ASJC) codes