The modification of RGD peptides to PKA signal responsive Polymer and the evaluation of its function

Moeko Ijuin, Jun Oishi, Kenji Kawamura, Jeong Hun Kang, Daisuke Asai, Yuko Sato, Yoshiki Katayama

Research output: Contribution to conferencePaper

Abstract

We recently proposed the novel gene-regulation polymer responding to cAMP-dependent protein kinase (PKA). However this polymer alone only had poor ability for the gene delivery into living cells. Thus it is difficult to evaluate the function of this polymer in living cells. On the other hand, it has been reported Arg-Gly-Asp (RGD) peptides modified polymer was efficiently deliveried genes into cells. In the present study, we modified the signal responsive polymer to RGD peptide for the introduction of polymer-DNA complex into living cells.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Ijuin, M., Oishi, J., Kawamura, K., Kang, J. H., Asai, D., Sato, Y., & Katayama, Y. (2006). The modification of RGD peptides to PKA signal responsive Polymer and the evaluation of its function. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.