The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU

Hiroyuki Kitao, Shinichi Kiyonari, Makoto Limori, Shinichiro Niimi, Yuki Kataoka, Shingo Akiyama, Keitaro Edahiro, Ryota Nakanishi, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Shingo Kanaji, Yoshihiro Kakeji, Yoshihiko Maehara

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2 Citations (Scopus)

Abstract

Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin (L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalJapanese Journal of Cancer and Chemotherapy
Volume43
Issue number6
Publication statusPublished - Jun 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kitao, H., Kiyonari, S., Limori, M., Niimi, S., Kataoka, Y., Akiyama, S., Edahiro, K., Nakanishi, R., Tokunaga, E., Saeki, H., Oki, E., Kanaji, S., Kakeji, Y., & Maehara, Y. (2016). The molecular aspect of the antitumor effect of oxaliplatin in combination with 5-FU. Japanese Journal of Cancer and Chemotherapy, 43(6), 707-714.