The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU

Hiroyuki Kitao, Shinichi Kiyonari, Makoto Iimori, Shinichiro Niimi, Yuki Kataoka, Shingo Akiyama, Keitaro Edahiro, Ryota Nakanishi, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Shingo Kanaji, Yoshihiro Kakeji, Yoshihiko Maehara

Research output: Contribution to journalArticle

Abstract

Platinum-based chemotherapeutic drugs as a component of combination chemotherapy are widely used in the treatment of cancer. In particular, oxaliplatin(L-OHP), one such platinum-based chemotherapeutic drug, has a synergistic effect in combination with 5-FU and Leucovorin for the treatment of advanced colorectal cancer. However, the underlying molecular mechanism of this synergistic effect has not been fully clarified yet. In this review, we summarize several updates about the in vitro action of oxaliplatin in human tumor cells and discuss the underlying mechanism of its synergistic effect with 5-FU.

Original languageEnglish
Pages (from-to)707-714
Number of pages8
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume43
Issue number6
Publication statusPublished - Jun 1 2016

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oxaliplatin
Platinum
Fluorouracil
Leucovorin
Combination Drug Therapy
Pharmaceutical Preparations
Colorectal Neoplasms
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU. / Kitao, Hiroyuki; Kiyonari, Shinichi; Iimori, Makoto; Niimi, Shinichiro; Kataoka, Yuki; Akiyama, Shingo; Edahiro, Keitaro; Nakanishi, Ryota; Tokunaga, Eriko; Saeki, Hiroshi; Oki, Eiji; Kanaji, Shingo; Kakeji, Yoshihiro; Maehara, Yoshihiko.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 43, No. 6, 01.06.2016, p. 707-714.

Research output: Contribution to journalArticle

Kitao, H, Kiyonari, S, Iimori, M, Niimi, S, Kataoka, Y, Akiyama, S, Edahiro, K, Nakanishi, R, Tokunaga, E, Saeki, H, Oki, E, Kanaji, S, Kakeji, Y & Maehara, Y 2016, 'The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 43, no. 6, pp. 707-714.
Kitao, Hiroyuki ; Kiyonari, Shinichi ; Iimori, Makoto ; Niimi, Shinichiro ; Kataoka, Yuki ; Akiyama, Shingo ; Edahiro, Keitaro ; Nakanishi, Ryota ; Tokunaga, Eriko ; Saeki, Hiroshi ; Oki, Eiji ; Kanaji, Shingo ; Kakeji, Yoshihiro ; Maehara, Yoshihiko. / The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2016 ; Vol. 43, No. 6. pp. 707-714.
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