The molecular pathogenesis of collagen-induced arthritis in mice - A model for rheumatoid arthritis

Rikard Holmdahl, Robert Bockermann, Johan Bäcklund, Hisakata Yamada

Research output: Contribution to journalReview articlepeer-review

129 Citations (Scopus)

Abstract

The most widely used model for rheumatoid arthritis is the collagen-induced arthritis (CIA) in mice. This model has gained acceptance since it is reproducible, well defined and has proven useful for development of new therapies for rheumatoid arthritis, as exemplified by the most recent advancement using TNFα neutralization treatment. The collagen-induced arthritis model, however, represents only certain pathways leading to arthritis and there is no consensus on how they operate. Nevertheless, we are beginning to understand the immune recognition structures, such as MHC molecules, lymphocyte receptors and type II collagen epitopes, which are of crucial importance for the development of this disease. These provide useful tools for further investigations of the pathogenesis of CIA as well as for understanding the pathogenesis of rheumatoid arthritis.

Original languageEnglish
Pages (from-to)135-147
Number of pages13
JournalAgeing Research Reviews
Volume1
Issue number1
DOIs
Publication statusPublished - Feb 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

Fingerprint Dive into the research topics of 'The molecular pathogenesis of collagen-induced arthritis in mice - A model for rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this