The morbillivirus receptor SLAM (CD150)

Hironobu Tatsuo, Yusuke Yanagi

Research output: Contribution to journalShort survey

53 Citations (Scopus)

Abstract

Morbilliviruses are highly contagious pathogens that cause some of the most devastating viral diseases of humans and animals, including measles virus (MV), canine distemper virus (CDV), and rinderpest virus (RPV). They replicate mainly in lymphoid organs throughout the body and cause severe immunosuppression accompanied with lymphopenia. We have recently shown that human, canine, and bovine signaling lymphocyte activation molecules (SLAMs; also known as CD150) act as cellular receptors for MV, CDV, and RPV, respectively. In these three morbilliviruses, all strains examined were shown to use SLAMs of their respective host species, and laboratory strains passaged on SLAM-negative cells were found to use, besides SLAM, alternative receptors, such as human CD46 for the Edmonston strain of MV. The use of SLAM as a receptor may be a property common to most, if not all, of the members of morbilliviruses. Human SLAM is a membrane glycoprotein selectively expressed on the cells of the immune system (immature thymocytes, activated lymphocytes, activated monocytes, and mature dendritic cells) and seems to mediate lymphocyte activation and to control interferon-γ production. The destruction and/or impairment of infected SLAM-positive cells may be a mechanism for the immunosuppression induced by morbilliviruses, but other mechanisms may be also involved.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalMICROBIOLOGY and IMMUNOLOGY
Volume46
Issue number3
DOIs
Publication statusPublished - Jan 1 2002

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Morbillivirus
Measles virus
Rinderpest virus
Canine Distemper Virus
Lymphocyte Activation
Immunosuppression
Lymphopenia
Membrane Glycoproteins
Virus Diseases
Thymocytes
Dendritic Cells
Interferons
Canidae
Monocytes
Immune System
Lymphocytes
Signaling Lymphocytic Activation Molecule Family Member 1

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

The morbillivirus receptor SLAM (CD150). / Tatsuo, Hironobu; Yanagi, Yusuke.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 46, No. 3, 01.01.2002, p. 135-142.

Research output: Contribution to journalShort survey

Tatsuo, Hironobu ; Yanagi, Yusuke. / The morbillivirus receptor SLAM (CD150). In: MICROBIOLOGY and IMMUNOLOGY. 2002 ; Vol. 46, No. 3. pp. 135-142.
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