The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori

Shigehiro Namiki, Tsuguru Fujii, Toru Shimada, Ryohei Kanzaki

Research output: Contribution to journalArticle

Abstract

How to wire a neural circuit is crucial for the functioning of the nervous system. Here, we describe the neuroanatomy of the olfactory neurons in the spli mutant strain of silkmoth (Bombyx mori) to investigate the function of a transcription factor involved in neuronal wiring in the central olfactory circuit. The genomic structure of the gene Bmacj6, which encodes a class IV POU domain transcription factor, is disrupted in the spli mutant. We report the neuroanatomical abnormality in the morphology of the antennal lobe projection neurons (PNs) that process the sex pheromone. In addition to the mis-targeting of dendrites and axons, we found axonal bifurcation within the PNs. These results indicate that the morphology of neurons in the pheromone processing pathway is modified by Bmacj6.

Original languageEnglish
Article number14050
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori'. Together they form a unique fingerprint.

  • Cite this