The nervous system involvement in human retroviral infection

Research output: Contribution to journalArticle

Abstract

Human T-lymphotropic virus type I (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM). A chronic inflammatory process has been implicated in HAM by a pathological study, but the exact mechanism still remains to be elucidated. Our quantitative polymerase chain reaction study indicated that the large increase in the HTLV-I proviral DNA in peripheral blood is associated with the development of HAM. The nucleotide sequence analysis of HTLV-I in central nervous system (CNS) tissue of HAM patients revealed that the sequences of HTLV-I genome were heterogenous in all cases, and that the pX-defective mutants were found frequently in the CNS. Thus, HTLV-I exists as quasispecies in vivo, as shown in the case of human immunodeficiency virus. It is possible that the HTLV-I pX microvariants contribute to the neural damage, since the pX gene products are essential for the transactivation of various cellular genes as well as for viral replication.

Original languageEnglish
Pages (from-to)1262-1264
Number of pages3
JournalClinical Neurology
Volume34
Issue number12
Publication statusPublished - 1994

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Nervous System
Viruses
Tropical Spastic Paraparesis
Infection
Spinal Cord Diseases
pX Genes
Central Nervous System
Nerve Tissue
Retroviridae
Transcriptional Activation
Sequence Analysis
HIV
Genome
Polymerase Chain Reaction
DNA
Genes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

The nervous system involvement in human retroviral infection. / Kira, Jun-Ichi.

In: Clinical Neurology, Vol. 34, No. 12, 1994, p. 1262-1264.

Research output: Contribution to journalArticle

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