The neurovascular unit in health and ischemic stroke

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The neurovascular unit (NVU), a minimal unit to exert neurological functions, is composed of neurons, astrocytes, endothelial cells, pericytes, and extracellular matrix proteins forming basal membranes. The cell components interact with one another and function cooperatively under both physiological and pathological conditions. Pericytes and astrocytes participate crucially in the formation and maintenance of the blood-brain barrier (BBB), the tight junction formed by endothelial cells, and regulate cerebral blood flow in response to neurological activities. The BBB actively regulate molecular import and export. The concept of the NVU is also useful for understanding pathogenesis and exploring therapeutic targets in various CNS disorders. In this review, recent research advances regarding the NVU and its components in health and ischemic stroke are summarized.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Volume74
Issue number4
Publication statusPublished - Apr 1 2016

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Pericytes
Blood-Brain Barrier
Astrocytes
Cerebrovascular Circulation
Endothelial Cells
Stroke
Tight Junctions
Extracellular Matrix Proteins
Health
Cellular Structures
Maintenance
Neurons
Membranes
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

The neurovascular unit in health and ischemic stroke. / Ago, Tetsuro.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 74, No. 4, 01.04.2016, p. 583-588.

Research output: Contribution to journalReview article

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