The normal body temperature lowering effect of aspirin in mice and its circadian rhythm

J. G. Song, Shigehiro Ohdo, N. Ogawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

It is generally believed that the effectiveness of salicylates, such as aspirin (ASP), is restricted to the lowering of the body temperature (BT) previously elevated by pyrogens and that salicylates have no effect on normal BT. We present here evidences which demonstrate that ASP does lower the normal BT of mice kept in a 24 degrees C environment. Male ICR mice, housed under a light-dark cycle (LD 12:12h) at a room temperature of 24 +/- 1 degree C and a humidity of 60 +/- 10% with food and water ad libitum, received intraperitoneal injections of ASP 25, 100 and 200 mg.kg-1. The animals showed a significant decline in their rectal temperature and the BT returned to the values that prevailed before drug administration within 4 h. There was an orderly, progressive dose-dependent decrease in BT. A significant circadian rhythm was demonstrated for ASP-induced hypothermal effect in mice. Although a significant circadian rhythm was also demonstrated for the plasma salicylate concentrations at 1 h after dosing, there seems to be no positive relationship between plasma drug concentrations and the drug response. The results suggest that ASP does affect normal BT regulation in mice and that the circadian rhythm change in ASP-induced hypothermal effect may be mainly due to the rhythms in the sensitivity of mice to the drug.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalYao xue xue bao = Acta pharmaceutica Sinica
Volume29
Issue number5
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Circadian Rhythm
Body Temperature
Aspirin
Salicylates
Pharmaceutical Preparations
Pyrogens
Inbred ICR Mouse
Temperature
Body Temperature Regulation
Photoperiod
Humidity
Intraperitoneal Injections
Food
Water

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The normal body temperature lowering effect of aspirin in mice and its circadian rhythm. / Song, J. G.; Ohdo, Shigehiro; Ogawa, N.

In: Yao xue xue bao = Acta pharmaceutica Sinica, Vol. 29, No. 5, 01.01.1994, p. 330-334.

Research output: Contribution to journalArticle

@article{8c33428264d84d219e950b6a47277a4d,
title = "The normal body temperature lowering effect of aspirin in mice and its circadian rhythm",
abstract = "It is generally believed that the effectiveness of salicylates, such as aspirin (ASP), is restricted to the lowering of the body temperature (BT) previously elevated by pyrogens and that salicylates have no effect on normal BT. We present here evidences which demonstrate that ASP does lower the normal BT of mice kept in a 24 degrees C environment. Male ICR mice, housed under a light-dark cycle (LD 12:12h) at a room temperature of 24 +/- 1 degree C and a humidity of 60 +/- 10{\%} with food and water ad libitum, received intraperitoneal injections of ASP 25, 100 and 200 mg.kg-1. The animals showed a significant decline in their rectal temperature and the BT returned to the values that prevailed before drug administration within 4 h. There was an orderly, progressive dose-dependent decrease in BT. A significant circadian rhythm was demonstrated for ASP-induced hypothermal effect in mice. Although a significant circadian rhythm was also demonstrated for the plasma salicylate concentrations at 1 h after dosing, there seems to be no positive relationship between plasma drug concentrations and the drug response. The results suggest that ASP does affect normal BT regulation in mice and that the circadian rhythm change in ASP-induced hypothermal effect may be mainly due to the rhythms in the sensitivity of mice to the drug.",
author = "Song, {J. G.} and Shigehiro Ohdo and N. Ogawa",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "29",
pages = "330--334",
journal = "Yao xue xue bao = Acta pharmaceutica Sinica",
issn = "0513-4870",
publisher = "Zhonghua Yixuehui Zazhishe",
number = "5",

}

TY - JOUR

T1 - The normal body temperature lowering effect of aspirin in mice and its circadian rhythm

AU - Song, J. G.

AU - Ohdo, Shigehiro

AU - Ogawa, N.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - It is generally believed that the effectiveness of salicylates, such as aspirin (ASP), is restricted to the lowering of the body temperature (BT) previously elevated by pyrogens and that salicylates have no effect on normal BT. We present here evidences which demonstrate that ASP does lower the normal BT of mice kept in a 24 degrees C environment. Male ICR mice, housed under a light-dark cycle (LD 12:12h) at a room temperature of 24 +/- 1 degree C and a humidity of 60 +/- 10% with food and water ad libitum, received intraperitoneal injections of ASP 25, 100 and 200 mg.kg-1. The animals showed a significant decline in their rectal temperature and the BT returned to the values that prevailed before drug administration within 4 h. There was an orderly, progressive dose-dependent decrease in BT. A significant circadian rhythm was demonstrated for ASP-induced hypothermal effect in mice. Although a significant circadian rhythm was also demonstrated for the plasma salicylate concentrations at 1 h after dosing, there seems to be no positive relationship between plasma drug concentrations and the drug response. The results suggest that ASP does affect normal BT regulation in mice and that the circadian rhythm change in ASP-induced hypothermal effect may be mainly due to the rhythms in the sensitivity of mice to the drug.

AB - It is generally believed that the effectiveness of salicylates, such as aspirin (ASP), is restricted to the lowering of the body temperature (BT) previously elevated by pyrogens and that salicylates have no effect on normal BT. We present here evidences which demonstrate that ASP does lower the normal BT of mice kept in a 24 degrees C environment. Male ICR mice, housed under a light-dark cycle (LD 12:12h) at a room temperature of 24 +/- 1 degree C and a humidity of 60 +/- 10% with food and water ad libitum, received intraperitoneal injections of ASP 25, 100 and 200 mg.kg-1. The animals showed a significant decline in their rectal temperature and the BT returned to the values that prevailed before drug administration within 4 h. There was an orderly, progressive dose-dependent decrease in BT. A significant circadian rhythm was demonstrated for ASP-induced hypothermal effect in mice. Although a significant circadian rhythm was also demonstrated for the plasma salicylate concentrations at 1 h after dosing, there seems to be no positive relationship between plasma drug concentrations and the drug response. The results suggest that ASP does affect normal BT regulation in mice and that the circadian rhythm change in ASP-induced hypothermal effect may be mainly due to the rhythms in the sensitivity of mice to the drug.

UR - http://www.scopus.com/inward/record.url?scp=0028188908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028188908&partnerID=8YFLogxK

M3 - Article

C2 - 7976349

AN - SCOPUS:0028188908

VL - 29

SP - 330

EP - 334

JO - Yao xue xue bao = Acta pharmaceutica Sinica

JF - Yao xue xue bao = Acta pharmaceutica Sinica

SN - 0513-4870

IS - 5

ER -