The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro

Makoto Kawamoto, Keigo Ozono, Yasuhiro Oyama, Akio Yamasaki, Yoshinao Oda, Hideya Onishi

Research output: Contribution to journalArticle

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Abstract

We previously reported that brain-derived neurotrophic factor (BDNF)/neurotrophic receptor tyrosine kinase 2 (NTRK2/TRKB) signaling contributes to induction of malignant phenotype of gallbladder cancer (GBC). Recently, pan-TRK inhibitors have been evaluated and their dramatic clinical activity is being shown for a variety of cancer types harboring an NTRK rearrangement in phase I trials. ONO-7579 is an oral pan-TRK inhibitor currently under investigation in phase I/II clinical trial for TRK-rearranged solid tumors. In this study, we evaluated the anticancer effect of ONO-7579 using GBC cells with or without KRAS mutant, NOZ, TYGBK-1. Our study showed that ONO-7579 had a suppressive effect on GBC proliferation in TYGBK-1, and on invasive potential and vascular endothelial growth factor expression in TYGBK-1 and NOZ. Our data indicated that ONO-7579 could be a promising treatment option for patients with GBC.

Original languageEnglish
Pages (from-to)1979-1986
Number of pages8
JournalAnticancer research
Volume38
Issue number4
DOIs
Publication statusPublished - Apr 2018

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Gallbladder Neoplasms
TYK2 Kinase
trkB Receptor
Phase II Clinical Trials
Clinical Trials, Phase I
Vascular Endothelial Growth Factor A
Neoplasms
Phenotype
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro. / Kawamoto, Makoto; Ozono, Keigo; Oyama, Yasuhiro; Yamasaki, Akio; Oda, Yoshinao; Onishi, Hideya.

In: Anticancer research, Vol. 38, No. 4, 04.2018, p. 1979-1986.

Research output: Contribution to journalArticle

Kawamoto, Makoto ; Ozono, Keigo ; Oyama, Yasuhiro ; Yamasaki, Akio ; Oda, Yoshinao ; Onishi, Hideya. / The novel selective pan-TRK inhibitor ONO-7579 exhibits antitumor efficacy against human gallbladder cancer in vitro. In: Anticancer research. 2018 ; Vol. 38, No. 4. pp. 1979-1986.
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