The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study

Hiroshi Nitta, Sayaka Katagiri, Toshiyuki Nagasawa, Yuichi Izumi, Isao Ishikawa, Hajime Izumiyama, Isao Uchimura, Masao Kanazawa, Hiroshige Chiba, Akira Matsuo, Kazunori Utsunomiya, Haruyasu Tanabe, Izumi Takei, Soichiro Asanami, Hiroshi Kajio, Toaki Ono, Yoichi Hayashi, Kiichi Ueki, Masatomi Tsuji, Yoichi KurachiToshikazu Yamanouchi, Yoshimi Ichinokawa, Toshiki Inokuchi, Akiko Fukui, Shigeru Miyazaki, Takashi Miyauchi, Reiko Kawahara, Hideki Ogiuchi, Narihito Yoshioka, Jun Negishi, Masatomo Mori, Kenji Mogi, Yasushi Saito, Hideki Tanzawa, Tetsuo Nishikawa, Norihiko Takada, Kishio Nanjo, Nobuo Morita, Naoto Nakamura, Narisato Kanamura, Hirofumi Makino, Fusanori Nishimura, Kunihisa Kobayashi, Yoshinori Higuchi, Toshiie Sakata, Shigetaka Yanagisawa, Chuwa Tei, Yuichi Ando, Nobuhiro Hanada, Shuji Inoue

Research output: Contribution to journalArticle

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Abstract

Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.

Original languageEnglish
Pages (from-to)677-686
Number of pages10
JournalJournal of Diabetes Investigation
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 2017

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Periodontitis
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Glycosylated Hemoglobin A
Odds Ratio
Confidence Intervals
Propensity Score
Tooth
Logistic Models
Regression Analysis
Incidence

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients : Results of a multicenter hospital-based cross-sectional study. / Nitta, Hiroshi; Katagiri, Sayaka; Nagasawa, Toshiyuki; Izumi, Yuichi; Ishikawa, Isao; Izumiyama, Hajime; Uchimura, Isao; Kanazawa, Masao; Chiba, Hiroshige; Matsuo, Akira; Utsunomiya, Kazunori; Tanabe, Haruyasu; Takei, Izumi; Asanami, Soichiro; Kajio, Hiroshi; Ono, Toaki; Hayashi, Yoichi; Ueki, Kiichi; Tsuji, Masatomi; Kurachi, Yoichi; Yamanouchi, Toshikazu; Ichinokawa, Yoshimi; Inokuchi, Toshiki; Fukui, Akiko; Miyazaki, Shigeru; Miyauchi, Takashi; Kawahara, Reiko; Ogiuchi, Hideki; Yoshioka, Narihito; Negishi, Jun; Mori, Masatomo; Mogi, Kenji; Saito, Yasushi; Tanzawa, Hideki; Nishikawa, Tetsuo; Takada, Norihiko; Nanjo, Kishio; Morita, Nobuo; Nakamura, Naoto; Kanamura, Narisato; Makino, Hirofumi; Nishimura, Fusanori; Kobayashi, Kunihisa; Higuchi, Yoshinori; Sakata, Toshiie; Yanagisawa, Shigetaka; Tei, Chuwa; Ando, Yuichi; Hanada, Nobuhiro; Inoue, Shuji.

In: Journal of Diabetes Investigation, Vol. 8, No. 5, 09.2017, p. 677-686.

Research output: Contribution to journalArticle

Nitta, H, Katagiri, S, Nagasawa, T, Izumi, Y, Ishikawa, I, Izumiyama, H, Uchimura, I, Kanazawa, M, Chiba, H, Matsuo, A, Utsunomiya, K, Tanabe, H, Takei, I, Asanami, S, Kajio, H, Ono, T, Hayashi, Y, Ueki, K, Tsuji, M, Kurachi, Y, Yamanouchi, T, Ichinokawa, Y, Inokuchi, T, Fukui, A, Miyazaki, S, Miyauchi, T, Kawahara, R, Ogiuchi, H, Yoshioka, N, Negishi, J, Mori, M, Mogi, K, Saito, Y, Tanzawa, H, Nishikawa, T, Takada, N, Nanjo, K, Morita, N, Nakamura, N, Kanamura, N, Makino, H, Nishimura, F, Kobayashi, K, Higuchi, Y, Sakata, T, Yanagisawa, S, Tei, C, Ando, Y, Hanada, N & Inoue, S 2017, 'The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study', Journal of Diabetes Investigation, vol. 8, no. 5, pp. 677-686. https://doi.org/10.1111/jdi.12633
Nitta, Hiroshi ; Katagiri, Sayaka ; Nagasawa, Toshiyuki ; Izumi, Yuichi ; Ishikawa, Isao ; Izumiyama, Hajime ; Uchimura, Isao ; Kanazawa, Masao ; Chiba, Hiroshige ; Matsuo, Akira ; Utsunomiya, Kazunori ; Tanabe, Haruyasu ; Takei, Izumi ; Asanami, Soichiro ; Kajio, Hiroshi ; Ono, Toaki ; Hayashi, Yoichi ; Ueki, Kiichi ; Tsuji, Masatomi ; Kurachi, Yoichi ; Yamanouchi, Toshikazu ; Ichinokawa, Yoshimi ; Inokuchi, Toshiki ; Fukui, Akiko ; Miyazaki, Shigeru ; Miyauchi, Takashi ; Kawahara, Reiko ; Ogiuchi, Hideki ; Yoshioka, Narihito ; Negishi, Jun ; Mori, Masatomo ; Mogi, Kenji ; Saito, Yasushi ; Tanzawa, Hideki ; Nishikawa, Tetsuo ; Takada, Norihiko ; Nanjo, Kishio ; Morita, Nobuo ; Nakamura, Naoto ; Kanamura, Narisato ; Makino, Hirofumi ; Nishimura, Fusanori ; Kobayashi, Kunihisa ; Higuchi, Yoshinori ; Sakata, Toshiie ; Yanagisawa, Shigetaka ; Tei, Chuwa ; Ando, Yuichi ; Hanada, Nobuhiro ; Inoue, Shuji. / The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients : Results of a multicenter hospital-based cross-sectional study. In: Journal of Diabetes Investigation. 2017 ; Vol. 8, No. 5. pp. 677-686.
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title = "The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital-based cross-sectional study",
abstract = "Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95{\%} confidence interval 1.1–1.6), glycated hemoglobin ≥8.0{\%} (64 mmol/mol; odds ratio 1.6; 95{\%} confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95{\%} confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0{\%} [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.",
author = "Hiroshi Nitta and Sayaka Katagiri and Toshiyuki Nagasawa and Yuichi Izumi and Isao Ishikawa and Hajime Izumiyama and Isao Uchimura and Masao Kanazawa and Hiroshige Chiba and Akira Matsuo and Kazunori Utsunomiya and Haruyasu Tanabe and Izumi Takei and Soichiro Asanami and Hiroshi Kajio and Toaki Ono and Yoichi Hayashi and Kiichi Ueki and Masatomi Tsuji and Yoichi Kurachi and Toshikazu Yamanouchi and Yoshimi Ichinokawa and Toshiki Inokuchi and Akiko Fukui and Shigeru Miyazaki and Takashi Miyauchi and Reiko Kawahara and Hideki Ogiuchi and Narihito Yoshioka and Jun Negishi and Masatomo Mori and Kenji Mogi and Yasushi Saito and Hideki Tanzawa and Tetsuo Nishikawa and Norihiko Takada and Kishio Nanjo and Nobuo Morita and Naoto Nakamura and Narisato Kanamura and Hirofumi Makino and Fusanori Nishimura and Kunihisa Kobayashi and Yoshinori Higuchi and Toshiie Sakata and Shigetaka Yanagisawa and Chuwa Tei and Yuichi Ando and Nobuhiro Hanada and Shuji Inoue",
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TY - JOUR

T1 - The number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients

T2 - Results of a multicenter hospital-based cross-sectional study

AU - Nitta, Hiroshi

AU - Katagiri, Sayaka

AU - Nagasawa, Toshiyuki

AU - Izumi, Yuichi

AU - Ishikawa, Isao

AU - Izumiyama, Hajime

AU - Uchimura, Isao

AU - Kanazawa, Masao

AU - Chiba, Hiroshige

AU - Matsuo, Akira

AU - Utsunomiya, Kazunori

AU - Tanabe, Haruyasu

AU - Takei, Izumi

AU - Asanami, Soichiro

AU - Kajio, Hiroshi

AU - Ono, Toaki

AU - Hayashi, Yoichi

AU - Ueki, Kiichi

AU - Tsuji, Masatomi

AU - Kurachi, Yoichi

AU - Yamanouchi, Toshikazu

AU - Ichinokawa, Yoshimi

AU - Inokuchi, Toshiki

AU - Fukui, Akiko

AU - Miyazaki, Shigeru

AU - Miyauchi, Takashi

AU - Kawahara, Reiko

AU - Ogiuchi, Hideki

AU - Yoshioka, Narihito

AU - Negishi, Jun

AU - Mori, Masatomo

AU - Mogi, Kenji

AU - Saito, Yasushi

AU - Tanzawa, Hideki

AU - Nishikawa, Tetsuo

AU - Takada, Norihiko

AU - Nanjo, Kishio

AU - Morita, Nobuo

AU - Nakamura, Naoto

AU - Kanamura, Narisato

AU - Makino, Hirofumi

AU - Nishimura, Fusanori

AU - Kobayashi, Kunihisa

AU - Higuchi, Yoshinori

AU - Sakata, Toshiie

AU - Yanagisawa, Shigetaka

AU - Tei, Chuwa

AU - Ando, Yuichi

AU - Hanada, Nobuhiro

AU - Inoue, Shuji

PY - 2017/9

Y1 - 2017/9

N2 - Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.

AB - Aims/Introduction: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods: This multicenter, hospital-based, cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results: After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications (P < 0.05). Conclusions: The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.

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U2 - 10.1111/jdi.12633

DO - 10.1111/jdi.12633

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VL - 8

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JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

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