The Oldest Japanese Case of Combined Central and Peripheral Demyelination, which Developed Nine Years after the First Instance of Optic Neuritis

Emi Nomura, Yuko Kawahara, Yoshio Omote, Koh Tadokoro, Mami Takemoto, Nozomi Hishikawa, Toru Yamashita, Hidenori Ogata, Koji Abe

Research output: Contribution to journalArticlepeer-review

Abstract

Combined central and peripheral demyelination (CCPD) causes demyelination in both the central and peripheral nervous systems. Anti-neurofascin 155 antibody plays an important pathogenic role in CCPD, but evidence concerning an association between this antibody and CCPD remains inconclusive. Although there have been no reports of precedent optic neuritis developing into CCPD, we herein report a Japanese man in whom optic neuritis recurred four times over nine years and who developed CCPD without positive anti-neurofascin 155 antibody. This case suggests the possibility of developing CCPD after optic nerve neuritis and the existence of an unknown antibody that induces CCPD.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalInternal Medicine
Volume60
Issue number2
DOIs
Publication statusPublished - Jan 15 2021

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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