The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review)

Masamitsu Konno, Ayumu Asai, Koichi Kawamoto, Naohiro Nishida, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

After the initial use of anti-folates for treatment of malignancies, folate metabolism has emerged as a rational diagnostic and therapeutic target in gastrointestinal cancer. The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway. Understanding of the one-carbon metabolism pathway has served to unravel the link between the causes and effects of cancer phenotypes leading to several seminal discoveries such as that of diadenosine tri-phosphate hydrolase, microRNAs, 5-FU and, more recently, trifluridine. In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle, S-adenocyl methionine serves hydrocarbons and polyamines that are critical for the epigenetic controls. The trans-sulfuration pathway is a critical component in the synthesis of glutathione, which is involved in the production of reactive oxygen species in cancer stem cells. Therefore, characterization of one-carbon metabolism is indispensable to the development of precision medicine in the context of cancer diagnostics and therapeutics. In the present study, we review the historical issues associated with one-carbon metabolism and highlight the recent advances in cancer research.

Original languageEnglish
Pages (from-to)1057-1063
Number of pages7
JournalInternational journal of oncology
Volume50
Issue number4
DOIs
Publication statusPublished - Apr 2017

Fingerprint

Gastrointestinal Neoplasms
Carbon
Folic Acid
Methionine
Neoplasms
Trifluridine
Therapeutics
Precision Medicine
Neoplastic Stem Cells
Polyamines
Hydrolases
Hydrocarbons
Metabolic Networks and Pathways
MicroRNAs
Epigenomics
Fluorouracil
Glycine
Serine
Glutathione
Reactive Oxygen Species

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review). / Konno, Masamitsu; Asai, Ayumu; Kawamoto, Koichi; Nishida, Naohiro; Satoh, Taroh; Doki, Yuichiro; Mori, Masaki; Ishii, Hideshi.

In: International journal of oncology, Vol. 50, No. 4, 04.2017, p. 1057-1063.

Research output: Contribution to journalReview article

Konno, Masamitsu ; Asai, Ayumu ; Kawamoto, Koichi ; Nishida, Naohiro ; Satoh, Taroh ; Doki, Yuichiro ; Mori, Masaki ; Ishii, Hideshi. / The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review). In: International journal of oncology. 2017 ; Vol. 50, No. 4. pp. 1057-1063.
@article{90a9aa5de4dd46cc8fa45fa5db3ecafb,
title = "The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review)",
abstract = "After the initial use of anti-folates for treatment of malignancies, folate metabolism has emerged as a rational diagnostic and therapeutic target in gastrointestinal cancer. The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway. Understanding of the one-carbon metabolism pathway has served to unravel the link between the causes and effects of cancer phenotypes leading to several seminal discoveries such as that of diadenosine tri-phosphate hydrolase, microRNAs, 5-FU and, more recently, trifluridine. In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle, S-adenocyl methionine serves hydrocarbons and polyamines that are critical for the epigenetic controls. The trans-sulfuration pathway is a critical component in the synthesis of glutathione, which is involved in the production of reactive oxygen species in cancer stem cells. Therefore, characterization of one-carbon metabolism is indispensable to the development of precision medicine in the context of cancer diagnostics and therapeutics. In the present study, we review the historical issues associated with one-carbon metabolism and highlight the recent advances in cancer research.",
author = "Masamitsu Konno and Ayumu Asai and Koichi Kawamoto and Naohiro Nishida and Taroh Satoh and Yuichiro Doki and Masaki Mori and Hideshi Ishii",
year = "2017",
month = "4",
doi = "10.3892/ijo.2017.3885",
language = "English",
volume = "50",
pages = "1057--1063",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "4",

}

TY - JOUR

T1 - The one-carbon metabolism pathway highlights therapeutic targets for gastrointestinal cancer (Review)

AU - Konno, Masamitsu

AU - Asai, Ayumu

AU - Kawamoto, Koichi

AU - Nishida, Naohiro

AU - Satoh, Taroh

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Ishii, Hideshi

PY - 2017/4

Y1 - 2017/4

N2 - After the initial use of anti-folates for treatment of malignancies, folate metabolism has emerged as a rational diagnostic and therapeutic target in gastrointestinal cancer. The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway. Understanding of the one-carbon metabolism pathway has served to unravel the link between the causes and effects of cancer phenotypes leading to several seminal discoveries such as that of diadenosine tri-phosphate hydrolase, microRNAs, 5-FU and, more recently, trifluridine. In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle, S-adenocyl methionine serves hydrocarbons and polyamines that are critical for the epigenetic controls. The trans-sulfuration pathway is a critical component in the synthesis of glutathione, which is involved in the production of reactive oxygen species in cancer stem cells. Therefore, characterization of one-carbon metabolism is indispensable to the development of precision medicine in the context of cancer diagnostics and therapeutics. In the present study, we review the historical issues associated with one-carbon metabolism and highlight the recent advances in cancer research.

AB - After the initial use of anti-folates for treatment of malignancies, folate metabolism has emerged as a rational diagnostic and therapeutic target in gastrointestinal cancer. The one-carbon metabolic pathway, which comprises three critical reactions (i.e., folate and methionine cycles), underlies this effect in conjunction with the trans-sulfuration pathway. Understanding of the one-carbon metabolism pathway has served to unravel the link between the causes and effects of cancer phenotypes leading to several seminal discoveries such as that of diadenosine tri-phosphate hydrolase, microRNAs, 5-FU and, more recently, trifluridine. In the folate cycle, glycine and serine fuel the mitochondrial enzymes SHMT2, MTHFD2 and ALDH1L2, which play critical roles in the cancer survival and proliferation presumably through purine production. In the methionine cycle, S-adenocyl methionine serves hydrocarbons and polyamines that are critical for the epigenetic controls. The trans-sulfuration pathway is a critical component in the synthesis of glutathione, which is involved in the production of reactive oxygen species in cancer stem cells. Therefore, characterization of one-carbon metabolism is indispensable to the development of precision medicine in the context of cancer diagnostics and therapeutics. In the present study, we review the historical issues associated with one-carbon metabolism and highlight the recent advances in cancer research.

UR - http://www.scopus.com/inward/record.url?scp=85018461509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018461509&partnerID=8YFLogxK

U2 - 10.3892/ijo.2017.3885

DO - 10.3892/ijo.2017.3885

M3 - Review article

C2 - 28259896

AN - SCOPUS:85018461509

VL - 50

SP - 1057

EP - 1063

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 4

ER -