The pedipump: A versatile, implantable pediatric ventricular assist device - Update IV

Brian W. Duncan, Kiyotaka Fukamachi, Lawrence D. Noble, David T. Dudzinski, Christine R. Flick, Hideyuki Fumoto, Akira Shiose, Yoko Arakawa, Tohru Takaseya, Fernando Casas, William A. Smith

Research output: Contribution to journalShort survey

7 Citations (Scopus)

Abstract

Cleveland Clinic's PediPump (Cleveland, OH, USA) is a ventricular assist device designed for the support of pediatric patients. The PediPump is a mixed-flow ventricular assist device with a magnetically suspended impeller measuring 10.5 mm in diameter by 64.5 mm in length. Progress and achievements for the PediPump program are considered according to the development project's three primary objectives: Basic engineering: along with size reductions, substantial design improvements have been incorporated in each design iteration including the motor, magnetic bearings, axial touch points, and heat transfer path; Anatomic modeling and device fitting studies: Techniques based on computed tomography and magnetic resonance imaging have been developed to create three-dimensional anatomic-modeling and device-fitting tools to facilitate device implantation and to assist in preoperative planning. For in vivo testing, to date, six acute (6-h duration) and nine chronic (30-day target duration) implantations have been performed in sheep; the implantation of the PediPump appears to be relatively easy with excellent hemodynamic performance and minimal hemolysis during support. Cleveland Clinic's PediPump program supported by the National Heart, Lung and Blood Institute's Pediatric Circulatory Support Program has led to the development of a pediatric ventricular assist device that has satisfactory performance in preclinical evaluation and appears to be ready to support a program of clinical testing.

Original languageEnglish
Pages (from-to)1005-1008
Number of pages4
JournalArtificial Organs
Volume33
Issue number11
DOIs
Publication statusPublished - Nov 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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    Duncan, B. W., Fukamachi, K., Noble, L. D., Dudzinski, D. T., Flick, C. R., Fumoto, H., Shiose, A., Arakawa, Y., Takaseya, T., Casas, F., & Smith, W. A. (2009). The pedipump: A versatile, implantable pediatric ventricular assist device - Update IV. Artificial Organs, 33(11), 1005-1008. https://doi.org/10.1111/j.1525-1594.2009.00946.x