TY - JOUR
T1 - The Pharmacokinetics of Salicylic Acid Following Single and Repeated Administration of Slow-release Formulations of Aspirin in Healthy Japanese Volunteers and the Effect of Dosing Time
AU - Yanaihara, Hiroshi
AU - Murakami, Katsuyuki
AU - Fukuda, Tamotsu
AU - Nakano, Shigeyuki
AU - Ohdo, Shigehiro
AU - Takaoka, Nobuyuki
AU - Ogawa, Nobuya
PY - 1985
Y1 - 1985
N2 - The effect of dosing time on salicylic acid (SA) kinetics after single oral administrations of two different aspirin formulations, a slow-release tablet (Verin®) and enteric-coated granules (Minimax), was investigated in 15 healthy Japanese men. Eight subjects received slow-release tablets and the other seven subjects received enteric-coated granules. Each aspirin formulation was given in the morning (8 : 30) or in the evening (20 : 30) in a randomly assigned cross-over study. After the single dose study, the SA kinetics following repeated administration of the two different aspirin.
AB - The effect of dosing time on salicylic acid (SA) kinetics after single oral administrations of two different aspirin formulations, a slow-release tablet (Verin®) and enteric-coated granules (Minimax), was investigated in 15 healthy Japanese men. Eight subjects received slow-release tablets and the other seven subjects received enteric-coated granules. Each aspirin formulation was given in the morning (8 : 30) or in the evening (20 : 30) in a randomly assigned cross-over study. After the single dose study, the SA kinetics following repeated administration of the two different aspirin.
UR - http://www.scopus.com/inward/record.url?scp=85024273071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024273071&partnerID=8YFLogxK
U2 - 10.3999/jscpt.16.759
DO - 10.3999/jscpt.16.759
M3 - Article
AN - SCOPUS:85024273071
SN - 0388-1601
VL - 16
SP - 759
EP - 768
JO - Japanese Journal of Clinical Pharmacology and Therapeutics
JF - Japanese Journal of Clinical Pharmacology and Therapeutics
IS - 4
ER -