The Pharmacokinetics of Salicylic Acid Following Single and Repeated Administration of Slow-release Formulations of Aspirin in Healthy Japanese Volunteers and the Effect of Dosing Time

Hiroshi Yanaihara, Katsuyuki Murakami, Tamotsu Fukuda, Shigeyuki Nakano, Shigehiro Ohdo, Nobuyuki Takaoka, Nobuya Ogawa

Research output: Contribution to journalArticle

Abstract

The effect of dosing time on salicylic acid (SA) kinetics after single oral administrations of two different aspirin formulations, a slow-release tablet (Verin®) and enteric-coated granules (Minimax), was investigated in 15 healthy Japanese men. Eight subjects received slow-release tablets and the other seven subjects received enteric-coated granules. Each aspirin formulation was given in the morning (8 : 30) or in the evening (20 : 30) in a randomly assigned cross-over study. After the single dose study, the SA kinetics following repeated administration of the two different aspirin.

Original languageEnglish
Pages (from-to)759-768
Number of pages10
JournalJapanese Journal of Clinical Pharmacology and Therapeutics
Volume16
Issue number4
DOIs
Publication statusPublished - Jan 1 1985
Externally publishedYes

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Salicylic Acid
Aspirin
Healthy Volunteers
Pharmacokinetics
Enteric-Coated Tablets
Cross-Over Studies
Tablets
Oral Administration

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

The Pharmacokinetics of Salicylic Acid Following Single and Repeated Administration of Slow-release Formulations of Aspirin in Healthy Japanese Volunteers and the Effect of Dosing Time. / Yanaihara, Hiroshi; Murakami, Katsuyuki; Fukuda, Tamotsu; Nakano, Shigeyuki; Ohdo, Shigehiro; Takaoka, Nobuyuki; Ogawa, Nobuya.

In: Japanese Journal of Clinical Pharmacology and Therapeutics, Vol. 16, No. 4, 01.01.1985, p. 759-768.

Research output: Contribution to journalArticle

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