The Pharmacokinetics of Salicylic Acid Following Single and Repeated Administration of Slow-release Formulations of Aspirin in Healthy Japanese Volunteers and the Effect of Dosing Time

Hiroshi Yanaihara, Katsuyuki Murakami, Tamotsu Fukuda, Shigeyuki Nakano, Shigehiro Ohdo, Nobuyuki Takaoka, Nobuya Ogawa

Research output: Contribution to journalArticle

Abstract

The effect of dosing time on salicylic acid (SA) kinetics after single oral administrations of two different aspirin formulations, a slow-release tablet (Verin®) and enteric-coated granules (Minimax), was investigated in 15 healthy Japanese men. Eight subjects received slow-release tablets and the other seven subjects received enteric-coated granules. Each aspirin formulation was given in the morning (8 : 30) or in the evening (20 : 30) in a randomly assigned cross-over study. After the single dose study, the SA kinetics following repeated administration of the two different aspirin.

Original languageEnglish
Pages (from-to)759-768
Number of pages10
JournalJapanese Journal of Clinical Pharmacology and Therapeutics
Volume16
Issue number4
DOIs
Publication statusPublished - 1985

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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